{"name":"CIBERSORT","description":"The Role of Circular RNA CDR1as/ciRS-7 in Regulating Tumor Microenvironment | CIBERSORT is an analytical tool developed by Newman et al. to provide an estimation of the abundances of member cell types in a mixed cell population, using gene expression data | Absolute mode (beta) is now available","homepage":"https://cibersort.stanford.edu/","biotoolsID":"CIBERSORT","biotoolsCURIE":"biotools:CIBERSORT","version":[],"otherID":[],"relation":[],"function":[{"operation":[{"uri":"http://edamontology.org/operation_3463","term":"Expression correlation analysis"},{"uri":"http://edamontology.org/operation_2436","term":"Gene-set enrichment analysis"},{"uri":"http://edamontology.org/operation_3792","term":"miRNA expression analysis"}],"input":[],"output":[],"note":null,"cmd":null}],"toolType":[],"topic":[{"uri":"http://edamontology.org/topic_2640","term":"Oncology"},{"uri":"http://edamontology.org/topic_0602","term":"Molecular interactions, pathways and networks"},{"uri":"http://edamontology.org/topic_0659","term":"Functional, regulatory and non-coding RNA"}],"operatingSystem":[],"language":[],"license":null,"collectionID":[],"maturity":null,"cost":null,"accessibility":null,"elixirPlatform":[],"elixirNode":[],"elixirCommunity":[],"link":[],"download":[],"documentation":[],"publication":[{"doi":"10.1038/nmeth.3337","pmid":"25822800","pmcid":"PMC4739640","type":[],"version":null,"note":null,"metadata":{"title":"Robust enumeration of cell subsets from tissue expression profiles","abstract":"© 2015 Nature America, Inc.We introduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expression profiles. When applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen and fixed tissues, including solid tumors, CIBERSORT outperformed other methods with respect to noise, unknown mixture content and closely related cell types. CIBERSORT should enable large-scale analysis of RNA mixtures for cellular biomarkers and therapeutic targets (http://cibersort.stanford.edu/).","date":"2015-04-29T00:00:00Z","citationCount":2303,"authors":[{"name":"Newman A.M."},{"name":"Liu C.L."},{"name":"Green M.R."},{"name":"Gentles A.J."},{"name":"Feng W."},{"name":"Xu Y."},{"name":"Hoang C.D."},{"name":"Diehn M."},{"name":"Alizadeh A.A."}],"journal":"Nature Methods"}}],"credit":[{"name":"Hailin Tang","email":"tanghl@sysucc.org.cn","url":null,"orcidid":null,"gridid":null,"rorid":null,"fundrefid":null,"typeEntity":"Person","typeRole":[],"note":null},{"name":"Xiaoming Xie","email":"xiexm@sysucc.org.cn","url":null,"orcidid":null,"gridid":null,"rorid":null,"fundrefid":null,"typeEntity":"Person","typeRole":[],"note":null}],"owner":"Pub2Tools","additionDate":"2019-11-14T20:00:36Z","lastUpdate":"2020-12-11T20:42:05Z","editPermission":{"type":"public","authors":[]},"validated":1,"homepage_status":0,"elixir_badge":0,"confidence_flag":"tool"}