count: 1
list:
- accessibility: null
  additionDate: '2017-12-18T00:04:45Z'
  biotoolsCURIE: biotools:cnssolve
  biotoolsID: cnssolve
  collectionID: []
  confidence_flag: null
  cost: null
  credit:
  - email: null
    fundrefid: null
    gridid: null
    name: Axel Brunger
    note: null
    orcidid: http://orcid.org/0000-0001-5121-2036
    rorid: null
    typeEntity: null
    typeRole: []
    url: null
  - email: null
    fundrefid: null
    gridid: null
    name: null
    note: null
    orcidid: null
    rorid: null
    typeEntity: Person
    typeRole:
    - Primary contact
    url: http://cns-online.org/v1.3/
  description: CNSsolve (Crystallography & NMR System or CNS) is an X-ray crystallography
    suite used for refinement, phasing, and molecular replacement
  documentation:
  - note: null
    type:
    - General
    url: http://cns-online.org/v1.3/
  download: []
  editPermission:
    authors: []
    type: private
  elixirCommunity: []
  elixirNode: []
  elixirPlatform: []
  elixir_badge: 0
  function:
  - cmd: null
    input: []
    note: null
    operation:
    - term: Phasing
      uri: http://edamontology.org/operation_3454
    output: []
  - cmd: null
    input: []
    note: null
    operation:
    - term: Molecular replacement
      uri: http://edamontology.org/operation_3455
    output: []
  homepage: http://cns-online.org
  homepage_status: 0
  language:
  - Fortran
  - C
  lastUpdate: '2024-11-25T14:27:30.618546Z'
  license: null
  link:
  - note: null
    type:
    - Software catalogue
    url: http://www.mybiosoftware.com/cnssolve-1-3-x-ray-crystallography-suite.html
  maturity: null
  name: CNSsolve
  operatingSystem:
  - Linux
  - Mac
  otherID: []
  owner: mbs_import
  publication:
  - doi: 10.1107/s0907444998003254
    metadata:
      abstract: 'A new software suite, called Crystallography & NMR System (CNS),
        has been developed for macromolecular structure determination by X-ray crystallography
        or solution nuclear magnetic resonance (NMR) spectroscopy. In contrast to
        existing structure-determination programs the architecture of CNS is highly
        flexible, allowing for extension to other structure-determination methods,
        such as electron microscopy and solid-state NMR spectroscopy. CNS has a hierarchical
        structure: a high-level hypertext markup language (HTML) user interface, task-oriented
        user input files, module files, a symbolic structure-determination language
        (CNS language), and low-level source code. Each layer is accessible to the
        user. The novice user may just use the HTML interface, while the more advanced
        user may use any of the other layers. The source code will be distributed,
        thus source-code modification is possible. The CNS language is sufficiently
        powerful and flexible that many new algorithms can be easily implemented in
        the CNS language without changes to the source code. The CNS language allows
        the user to perform operations on data structures, such as structure factors,
        electron-density maps, and atomic properties. The power of the CNS language
        has been demonstrated by the implementation of a comprehensive set of crystallographic
        procedures for phasing, density modification and refinement. User-friendly
        task-oriented input files are available for nearly all aspects of macromolecular
        structure determination by X-ray crystallography and solution NMR. © 1998
        International Union of Crystallography all rights reserved.'
      authors:
      - name: Brunger A.T.
      - name: Adams P.D.
      - name: Clore G.M.
      - name: Delano W.L.
      - name: Gros P.
      - name: Grossekunstleve R.W.
      - name: Jiang J.S.
      - name: Kuszewski J.
      - name: Nilges M.
      - name: Pannu N.S.
      - name: Read R.J.
      - name: Rice L.M.
      - name: Simonson T.
      - name: Warren G.L.
      citationCount: 17090
      date: '1998-09-01T00:00:00Z'
      journal: 'Acta Crystallographica Section D: Biological Crystallography'
      title: 'Crystallography & NMR system: A new software suite for macromolecular
        structure determination'
    note: null
    pmcid: null
    pmid: '9757107'
    type: []
    version: null
  - doi: 10.1038/nprot.2007.406
    metadata:
      abstract: Version 1.2 of the software system, termed Crystallography and NMR
        system (CNS), for crystallographic and NMR structure determination has been
        released. Since its first release, the goals of CNS have been (i) to create
        a flexible computational framework for exploration of new approaches to structure
        determination, (ii) to provide tools for structure solution of difficult or
        large structures, (iii) to develop models for analyzing structural and dynamical
        properties of macromolecules and (iv) to integrate all sources of information
        into all stages of the structure determination process. Version 1.2 includes
        an improved model for the treatment of disordered solvent for crystallographic
        refinement that employs a combined grid search and least-squares optimization
        of the bulk solvent model parameters. The method is more robust than previous
        implementations, especially at lower resolution, generally resulting in lower
        R values. Other advances include the ability to apply thermal factor sharpening
        to electron density maps. Consistent with the modular design of CNS, these
        additions and changes were implemented in the high-level computing language
        of CNS. © 2007 Nature Publishing Group.
      authors:
      - name: Brunger A.T.
      citationCount: 1177
      date: '2007-11-15T00:00:00Z'
      journal: Nature Protocols
      title: Version 1.2 of the crystallography and nmr system
    note: null
    pmcid: null
    pmid: '18007608'
    type: []
    version: null
  relation: []
  toolType:
  - Command-line tool
  topic:
  - term: NMR
    uri: http://edamontology.org/topic_0593
  - term: Molecular modelling
    uri: http://edamontology.org/topic_2275
  - term: Crystallography
    uri: http://edamontology.org/topic_2828
  - term: X-ray crystallography
    uri: http://edamontology.org/topic_2828
  validated: 1
  version:
  - '1.3'
next: null
previous: null
