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                    "note": "Run nnUnet pretrained on Task004_Hippocampus MRI data targeting posterior and anterior parts of the hippocampus",
                    "cmd": "docker run --rm -v /host/dataset/study_001:/home/eucaim/nnUNet_input -v /host/data_out:/home/eucaim/nnUNet_output --gpus all nnunet-hippocampus-segmentation"
                },
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                            "uri": "http://edamontology.org/operation_3553",
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                                "term": "Raw image"
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                    "note": "Run nnUnet pretrained on Task169_BrainTumorPET targeting are brain tumor",
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                    ],
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                        "authors": [],
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                    "note": null,
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                }
            ],
            "toolType": [
                "Plug-in",
                "Command-line tool",
                "Web service"
            ],
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                    "term": "FAIR data"
                }
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            ],
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            "elixirCommunity": [],
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                    ],
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                }
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            "download": [],
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                    "url": "https://github.com/IFCA-Advanced-Computing/FAIR_eva/blob/main/docs/index.md",
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                },
                {
                    "url": "https://gitlabpages.ifca.es/fair-eva-guide-608baa/",
                    "type": [
                        "User manual"
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                        "Maintainer",
                        "Documentor"
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                {
                    "name": "David Rodríguez",
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                            "term": "Aggregation"
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                        {
                            "uri": "http://edamontology.org/operation_0331",
                            "term": "Variant effect prediction"
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                    "input": [],
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                    "note": null,
                    "cmd": null
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            ],
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                "Command-line tool"
            ],
            "topic": [
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                    "uri": "http://edamontology.org/topic_0199",
                    "term": "Genetic variation"
                },
                {
                    "uri": "http://edamontology.org/topic_3474",
                    "term": "Machine learning"
                },
                {
                    "uri": "http://edamontology.org/topic_0078",
                    "term": "Proteins"
                },
                {
                    "uri": "http://edamontology.org/topic_0219",
                    "term": "Data submission, annotation and curation"
                },
                {
                    "uri": "http://edamontology.org/topic_3068",
                    "term": "Literature and language"
                }
            ],
            "operatingSystem": [
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                "Linux",
                "Windows"
            ],
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            "license": null,
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                    "note": null,
                    "metadata": {
                        "title": "SoluProtMutDB: A manually curated database of protein solubility changes upon mutations",
                        "abstract": "© 2022 The Author(s)Protein solubility is an attractive engineering target primarily due to its relation to yields in protein production and manufacturing. Moreover, better knowledge of the mutational effects on protein solubility could connect several serious human diseases with protein aggregation. However, we have limited understanding of the protein structural determinants of solubility, and the available data have mostly been scattered in the literature. Here, we present SoluProtMutDB – the first database containing data on protein solubility changes upon mutations. Our database accommodates 33 000 measurements of 17 000 protein variants in 103 different proteins. The database can serve as an essential source of information for the researchers designing improved protein variants or those developing machine learning tools to predict the effects of mutations on solubility. The database comprises all the previously published solubility datasets and thousands of new data points from recent publications, including deep mutational scanning experiments. Moreover, it features many available experimental conditions known to affect protein solubility. The datasets have been manually curated with substantial corrections, improving suitability for machine learning applications. The database is available at loschmidt.chemi.muni.cz/soluprotmutdb.",
                        "date": "2022-01-01T00:00:00Z",
                        "citationCount": 0,
                        "authors": [
                            {
                                "name": "Velecky J."
                            },
                            {
                                "name": "Hamsikova M."
                            },
                            {
                                "name": "Stourac J."
                            },
                            {
                                "name": "Musil M."
                            },
                            {
                                "name": "Damborsky J."
                            },
                            {
                                "name": "Bednar D."
                            },
                            {
                                "name": "Mazurenko S."
                            }
                        ],
                        "journal": "Computational and Structural Biotechnology Journal"
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                }
            ],
            "credit": [
                {
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            "name": "AutoProSeq - automatic classification of sequence types for prostate mpMRI",
            "description": "XGBoost-based automatic classification of sequence types for prostate mpMRI into T2W, DWI, ADC, DCE and others (any other sequence type) using metadata alone. Works as a CLI, allows direct application to DICOM datasets or CSV/tsv/Excel/parquet datasets, features integration for Orthanc and DICOM-web as RESTful APIs. This was applied to all data on ProCAncer-I to derive initial results for sequence types. Refines predictions using rule-based heuristics for T2W, DWI and ADC.",
            "homepage": "https://harbor.eucaim.cancerimage.eu/harbor/projects/4/repositories/champ-autoproseq",
            "biotoolsID": "auto-prostate-sequence-classifier",
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                    ],
                    "input": [
                        {
                            "data": {
                                "uri": "http://edamontology.org/data_3424",
                                "term": "Raw image"
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                            ]
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                    ],
                    "output": [
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                            "data": {
                                "uri": "http://edamontology.org/data_0968",
                                "term": "Keyword"
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                                    "uri": "http://edamontology.org/format_3752",
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                    ],
                    "note": "The input can be provided as a DICOM dataset (which will require --dicom-recursion, details below or in the documentation) or as a single DICOM study. This command will print a CSV with 5 columns:  i) patient_id, ii) study_uid, iii) series_uid, iv) classification from the XGBoost model, v) classification after heuristics-based corrections.\nThe sequence classification is performed between T2W, DWI, ADC, DCE or others. The provided <dicom-recursion> refers to the number of folders until a DICOM series is found. So if the provided input is a patient folder with nested studies with nested series, the level of DICOM recursion should be 2. If the provided input is a directory with patient folders, the level of DICOM recursion should be 3.",
                    "cmd": "docker run -v <dir-with-dicom>:/data  harbor.eucaim.cancerimage.eu/processing-tools/champ-autoproseq --dicom_recursion <dicom-recursion> --input_paths /data"
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            "license": "MIT",
            "collectionID": [
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            "maturity": "Emerging",
            "cost": "Free of charge (with restrictions)",
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            "elixirCommunity": [],
            "link": [
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                    "type": [
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                    "note": "Repository containing code, README and additional usage information for this tool."
                }
            ],
            "download": [],
            "documentation": [
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                    "type": [
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                    "note": "Repository containing the code, README and additional information on how to run the tool. If used as an API (when integrated with Orthanc or DICOM-web), the documentation is available upon launching the API at <api-url>/docs."
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            ],
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                    "pmcid": "PMC12187622",
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                        "title": "Automatic sequence identification in multicentric prostate multiparametric MRI datasets for clinical machine-learning",
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            "description": "The purpose of the tool is to provide a complete framework for automatic detection of image quality for Breast DCE MR images. The assessment is performed on the first post-contrast dynamic phase in order to assess the most clinically relevant sequence among a number of identical acquisitions. Two categories are available for image classification, i.e. high and low quality, depending on the level of noise, degree of blurring and presence of artifacts.",
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                    "term": "MRI"
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                    "term": "Data quality management"
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                    "term": "Oncology"
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        },
        {
            "name": "DICOM defacing anonymisation",
            "description": "This tool can be used to remove facial features (\"defacing\") from DICOM images. It may be used 1) only for facial removing, or 2) for a complete import and anonymization using DICOM transfer. Defaced images needs to be manually quality checked, and this is done through a web interface  to a local server supplied with the Docker containers.",
            "homepage": "https://www.dicom2usb.com",
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                "Desktop application",
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                    "term": "Medical imaging"
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                    "term": "Data protection"
                }
            ],
            "operatingSystem": [
                "Linux",
                "Windows",
                "Mac"
            ],
            "language": [],
            "license": "Proprietary",
            "collectionID": [
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            ],
            "maturity": "Emerging",
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            "accessibility": "Restricted access",
            "elixirPlatform": [],
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            "confidence_flag": "tool"
        },
        {
            "name": "APE",
            "description": "APE (the Automated Pipeline Explorer) as a command-line tool and API for automated composition of scientific workflows. APE is easily configured to a new application domain by providing it with a domain ontology and semantically annotated tools. It can then be used to synthesize purpose-specific workflows based on a specification of the available workflow inputs, desired outputs and possibly additional constraints.",
            "homepage": "https://github.com/sanctuuary/APE/",
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            "biotoolsCURIE": "biotools:ape",
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            "otherID": [],
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                {
                    "operation": [
                        {
                            "uri": "http://edamontology.org/operation_3429",
                            "term": "Generation"
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                    ],
                    "input": [
                        {
                            "data": {
                                "uri": "http://edamontology.org/data_0949",
                                "term": "Workflow metadata"
                            },
                            "format": [
                                {
                                    "uri": "http://edamontology.org/format_3464",
                                    "term": "JSON"
                                }
                            ]
                        }
                    ],
                    "output": [
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                            "data": {
                                "uri": "http://edamontology.org/data_0949",
                                "term": "Workflow metadata"
                            },
                            "format": [
                                {
                                    "uri": "http://edamontology.org/format_3604",
                                    "term": "SVG"
                                },
                                {
                                    "uri": "http://edamontology.org/format_3857",
                                    "term": "CWL"
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                            ]
                        }
                    ],
                    "note": null,
                    "cmd": null
                }
            ],
            "toolType": [
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                "Command-line tool"
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                    "uri": "http://edamontology.org/topic_0089",
                    "term": "Ontology and terminology"
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                    "term": "Bioinformatics"
                }
            ],
            "operatingSystem": [
                "Mac",
                "Windows",
                "Linux"
            ],
            "language": [
                "Java"
            ],
            "license": "Apache-2.0",
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            "maturity": "Mature",
            "cost": "Free of charge",
            "accessibility": "Open access",
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                    "type": [
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                    "note": null
                }
            ],
            "download": [
                {
                    "url": "https://mvnrepository.com/artifact/io.github.sanctuuary/APE/2.1.7",
                    "type": "Software package",
                    "note": "Download APE java library or the CLI",
                    "version": "2.1.7"
                }
            ],
            "documentation": [
                {
                    "url": "https://ape-framework.readthedocs.io/",
                    "type": [
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                    "note": null
                }
            ],
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                    "metadata": null
                },
                {
                    "doi": "10.1021/acs.jproteome.0c00983",
                    "pmid": "33720735",
                    "pmcid": "PMC8041394",
                    "type": [
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                    "version": null,
                    "note": null,
                    "metadata": {
                        "title": "APE in the Wild: Automated Exploration of Proteomics Workflows in the bio.tools Registry",
                        "abstract": "",
                        "date": "2021-04-02T00:00:00Z",
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                        "journal": "Journal of Proteome Research"
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        },
        {
            "name": "HBAT",
            "description": "HBAT (Hydrogen Bond Analysis Tool) is a package to automate the analysis of potential hydrogen bonds and similar type of weak interactions in macromolecular structures, available in Protein Data Bank (PDB) file format. HBAT uses a geometric approach to identify molecular interactions by analysing distance and angular criteria.\n\nHBAT 1.1 was released in 2007 as closed source Windows binary and continue to be available via SourceForge. \n\nHBAT 2.0 was introduced in 2025 and a completed rewrite of original implementation with cross-platform support. HBAT 2.0 is open sourced under MIT License.",
            "homepage": "https://hbat.abhishek-tiwari.com",
            "biotoolsID": "hbat",
            "biotoolsCURIE": "biotools:hbat",
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                "1.1, 1.0"
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            "otherID": [],
            "relation": [],
            "function": [
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                    ],
                    "input": [
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                    "output": [
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                                "term": "Protein hydrogen bonds"
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                    "note": null,
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            ],
            "toolType": [
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                "Desktop application"
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                {
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                    "term": "Proteins"
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            ],
            "operatingSystem": [
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                "Windows",
                "Mac"
            ],
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            "link": [
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                {
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            ],
            "download": [
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                {
                    "url": "https://github.com/abhishektiwari/hbat/releases",
                    "type": "Binaries",
                    "note": "Mac and Linux Binaries including  AppImage, .deb, standalone executables.",
                    "version": "2.x"
                },
                {
                    "url": "https://sourceforge.net/projects/hbat/",
                    "type": "Binaries",
                    "note": "Windows Binaries download from SourceForge",
                    "version": "1.0, 1.1"
                }
            ],
            "documentation": [
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                    "url": "https://hbat.abhishek-tiwari.com",
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            "publication": [
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                    "pmid": "18467777",
                    "pmcid": null,
                    "type": [
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                    ],
                    "version": null,
                    "note": "Peer-reviewed paper for HBAT 1.0",
                    "metadata": null
                },
                {
                    "doi": "10.5281/zenodo.17645321",
                    "pmid": null,
                    "pmcid": null,
                    "type": [
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                    ],
                    "version": null,
                    "note": "Preprint for HBAT 2.x software",
                    "metadata": null
                }
            ],
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                    "url": "https://www.abhishek-tiwari.com",
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        },
        {
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            "description": "This package performs in-silico MeOX + TMS derivatization (as described e.g. in https://doi.org/10.1021/acs.analchem.7b01010):\n\nMethoximation: ketone R(C=O)R' and aldehyde (-HC=O) carbonyl groups are substituted with -C=NOCH3\nTrimethylsilylation: the acidic hydrogen in -OH, -SH, -COOH, -NH2, -NHR, =NH, the hydrogen is substituted with -Si(CH3)3 The substitution doesn't always have to happen; its probability is currently hardcoded in the package. Typically, multiple substitution attempts are run on each input molecule, and all distinct results are gathered.\nKnown limitation is methoximation on cycles which should be broken. This is not implemented yet.",
            "homepage": "https://github.com/RECETOX/gc-meox-tms",
            "biotoolsID": "gc-meox-tms",
            "biotoolsCURIE": "biotools:gc-meox-tms",
            "version": [],
            "otherID": [],
            "relation": [],
            "function": [
                {
                    "operation": [
                        {
                            "uri": "http://edamontology.org/operation_0231",
                            "term": "Sequence editing"
                        }
                    ],
                    "input": [
                        {
                            "data": {
                                "uri": "http://edamontology.org/data_2301",
                                "term": "SMILES string"
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                        }
                    ],
                    "output": [
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                                "uri": "http://edamontology.org/data_2301",
                                "term": "SMILES string"
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                        }
                    ],
                    "note": "Produces MeOX/TMS derivatives of given compounds",
                    "cmd": "add_derivatization_groups()"
                }
            ],
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                    "term": "Medical imaging"
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