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Multiple withinsession acquisitions provide extremely high contrast to noise, making the data amenable to a wide range of analytic approaches including automated computational analysis. 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and design" } ], "operatingSystem": [], "language": [ "Python" ], "license": "GPL-3.0", "collectionID": [], "maturity": "Emerging", "cost": "Free of charge", "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/bio2byte/constava", "type": [ "Repository" ], "note": null } ], "download": [ { "url": "https://github.com/Bio2Byte/constava/releases/tag/v1.1.0", "type": "Source code", "note": "Source code in tar.gz or zip formats.", "version": "1.1.0" } ], "documentation": [ { "url": "https://pypi.org/project/constava/", "type": [ "Command-line options" ], "note": "Table of content: \nDescription\nInstallation\nPrerequisites\nInstallation through PyPI\nInstallation from the source\nUsage\nExecution from the command line\nExtracting backbone dihedrals from a trajectory\nAnalyzing a conformational ensemble\nGenerating custom conformational state models\nExecution as a python library\nExtracting backbone dihedrals as a 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W.V., D.R., G.O. and D.B. provided supervision. W.V. provided the NMR data and directed the project." }, { "name": "José Gavalda-Garcia", "email": null, "url": "https://bio2byte.be/people/38", "orcidid": "https://orcid.org/0000-0001-6431-3442", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": "J.G.-G. and D.B. developed, implemented and validated the method." }, { "name": "David Bickel", "email": null, "url": "https://bio2byte.be/people/47", "orcidid": "https://orcid.org/0000-0003-0332-8338", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": "W.V., D.R., G.O. and D.B. provided supervision. J.G.-G. and D.B. developed, implemented and validated the method." }, { "name": "Adrián Díaz", "email": "adrian.diaz@vub.be", "url": "https://bio2byte.be/people/48", "orcidid": "https://orcid.org/0000-0003-0165-1318", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Maintainer" ], "note": "A.D. contributed in the distribution of this software." }, { "name": "Daniele Raimondi", "email": null, "url": "https://orcid.org/0000-0003-1157-1899", "orcidid": "https://orcid.org/0000-0003-1157-1899", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Contributor" ], "note": "W.V., D.R. and G.O. conceptualised the study. 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W.V., D.R., G.O. and D.B. provided supervision." }, { "name": "Bio2Byte", "email": "bio2byte@vub.be", "url": "https://bio2byte.be", "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Institute", "typeRole": [], "note": null }, { "name": "Joel Roca-Martinez", "email": null, "url": "https://orcid.org/0000-0002-4313-3845", "orcidid": "https://orcid.org/0000-0002-4313-3845", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Contributor" ], "note": "J.R.-M. performed the MD simulations." } ], "owner": "adrian.diaz", "additionDate": "2025-09-23T08:54:29.614497Z", "lastUpdate": "2025-09-23T08:54:29.626822Z", "editPermission": { "type": "group", "authors": [ "wvranken@vub.ac.be", "adrian.diaz" ] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "methylR", "description": "Graphical interface for comprehensive DNA methylation array data analysis.", "homepage": "https://methylr.research.liu.se", "biotoolsID": "methylr", "biotoolsCURIE": "biotools:methylr", "version": [], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3204", "term": "Methylation analysis" }, { "uri": "http://edamontology.org/operation_3891", "term": "Essential dynamics" }, { "uri": "http://edamontology.org/operation_2436", "term": "Gene-set enrichment analysis" }, { "uri": "http://edamontology.org/operation_3928", "term": "Pathway analysis" }, { "uri": "http://edamontology.org/operation_2939", "term": "Principal component visualisation" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_3110", "term": "Raw microarray data" }, "format": [] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_0916", "term": "Gene report" }, "format": [] }, { "data": { "uri": "http://edamontology.org/data_1636", "term": "Heat map" }, "format": [] }, { "data": { "uri": "http://edamontology.org/data_3754", "term": "GO-term enrichment data" }, "format": [] }, { "data": { "uri": "http://edamontology.org/data_3953", "term": "Pathway overrepresentation data" }, "format": [] } ], "note": null, "cmd": null } ], "toolType": [ "Web application", "Desktop application" ], "topic": [ { "uri": "http://edamontology.org/topic_3295", "term": "Epigenetics" }, { "uri": "http://edamontology.org/topic_3518", "term": "Microarray experiment" }, { "uri": "http://edamontology.org/topic_0654", "term": "DNA" }, { "uri": "http://edamontology.org/topic_0602", "term": "Molecular interactions, pathways and networks" }, { "uri": "http://edamontology.org/topic_3170", "term": "RNA-Seq" } ], "operatingSystem": [ "Mac", "Linux", "Windows" ], "language": [ "JavaScript", "R" ], "license": "GPL-3.0", "collectionID": [], "maturity": null, "cost": "Free of charge", "accessibility": "Open access", "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/JD2112/methylr", "type": [ "Repository" ], "note": null }, { "url": "https://groups.google.com/g/methylr", "type": [ "Discussion forum" ], "note": null }, { "url": "https://sourceforge.net/projects/methylr/", "type": [ "Repository" ], "note": null }, { "url": "http://methylr.netlify.app", "type": [ "Other" ], "note": null } ], "download": [ { "url": "https://hub.docker.com/r/jd21/methylr", "type": "Container file", "note": null, "version": null } ], "documentation": [ { "url": "https://methylr.netlify.app/methylysis", "type": [ "User manual" ], "note": null } ], "publication": [ { "doi": "10.1093/bioinformatics/btad184", "pmid": "37039839", "pmcid": "PMC10125902", "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "methylR: a graphical interface for comprehensive DNA methylation array data analysis", "abstract": "Motivation: DNA methylation analysis using arrays is a widely used method in research and clinical studies to study Epigenetics. Although several packages have been published to incur the results, most of them require a deep computational knowledge to perform the analysis. To resolve the limitation and to offer an easily accessible solution for researchers, we developed methylR a graphical tool that can analyze not only the raw data but also performs different downstream analyses with a few mouse clicks. Results: We used standard and established open-source published packages or pipelines in methylR. We evaluated a publicly available dataset and compared the published results with those obtained with our tool. We implemented eight downstream analysis modules that can perform multidimensional analyses to pathway enrichment. Although the main application is designed for Illumina DNA methylation array data analysis, we made the accessory modules suitable for other kinds of data analysis as well. 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