Resource List
List all resources, or create a new resource.
GET /api/tool
{ "count": 30400, "next": "?page=2", "previous": null, "list": [ { "name": "HYMET", "description": "Hybrid Metagenomic Tool", "homepage": "https://github.com/inesbmartins02/HYMET", "biotoolsID": "hymet", "biotoolsCURIE": "biotools:hymet", "version": [ "1.0.0" ], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3460", "term": "Taxonomic classification" } ], "input": [], "output": [], "note": null, "cmd": null } ], "toolType": [], "topic": [], "operatingSystem": [], "language": [], "license": null, "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "inesbrancomartins", "additionDate": "2025-05-08T16:21:08.567634Z", "lastUpdate": "2025-05-08T16:21:08.570771Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "EUCAIM ETL toolset", "description": "Modular toolchain for an extensible and customizable ETL pipeline that extracts, transforms, and loads clinical data and medical imaging metadata, applying dataset-specific mappings to generate outputs compatible with the EUCAIM Common Data Model (CDM). Its design aims to minimize manual data preparation efforts and facilitate customization and integration with other components, such as data quality assurance tools.\nContainerized, currently supports input datasets in CSV, JSON, XLSX.", "homepage": "https://bahiasoftware.es/home", "biotoolsID": "eetl_toolset", "biotoolsCURIE": "biotools:eetl_toolset", "version": [ "0.9.1" ], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_0335", "term": "Data formatting" } ], "input": [], "output": [], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_3431", "term": "Data deposition" } ], "input": [], "output": [], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_0336", "term": "Format validation" } ], "input": [], "output": [], "note": null, "cmd": null } ], "toolType": [ "Workflow", "Library" ], "topic": [ { "uri": "http://edamontology.org/topic_3345", "term": "Data identity and mapping" }, { "uri": "http://edamontology.org/topic_0769", "term": "Workflows" } ], "operatingSystem": [ "Linux", "Windows" ], "language": [ "Java", "Python" ], "license": "Apache-2.0", "collectionID": [ "EUCAIM" ], "maturity": "Emerging", "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "victorsp", "additionDate": "2025-04-24T13:00:12.867477Z", "lastUpdate": "2025-05-08T09:29:42.363560Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "Hyperparameter Scoring Hi-C", "description": "Regression-based scoring functions for predicted Hi-C matrices to enhance hyperparameter optimization.", "homepage": "https://github.com/joachimwolff/hyperparameterScoringHiC", "biotoolsID": "hyperparameter_scoring_hi-c", "biotoolsCURIE": "biotools:hyperparameter_scoring_hi-c", "version": [], "otherID": [], "relation": [], "function": [], "toolType": [], "topic": [], "operatingSystem": [], "language": [], "license": null, "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "joachimwolff", "additionDate": "2025-05-08T09:17:49.360624Z", "lastUpdate": "2025-05-08T09:17:49.363010Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "AMICI", "description": "AMICI provides a multi-language (Python, C++, Matlab) interface for the SUNDIALS solvers CVODES (for ordinary differential equations) and IDAS (for algebraic differential equations). AMICI allows the user to read differential equation models specified as SBML or PySB and automatically compiles such models into .mex simulation files (Matlab), C++ executables or Python modules.\n\nBeyond forward integration, the compiled simulation file also allows for forward sensitivity analysis, steady state sensitivity analysis and adjoint sensitivity analysis for likelihood-based output functions.\n\nThe interface was designed to provide routines for efficient gradient computation in parameter estimation of biochemical reaction models but it is also applicable to a wider range of differential equation constrained optimization problems.", "homepage": "https://github.com/AMICI-dev/AMICI", "biotoolsID": "AMICI", "biotoolsCURIE": "biotools:AMICI", "version": [], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3562", "term": "Network simulation" }, { "uri": "http://edamontology.org/operation_2426", "term": "Modelling and simulation" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_2600", "term": "Pathway or network" }, "format": [ { "uri": "http://edamontology.org/format_2585", "term": "SBML" }, { "uri": "http://edamontology.org/format_4015", "term": "PEtab" } ] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_3870", "term": "Trajectory data" }, "format": [ { "uri": "http://edamontology.org/format_2330", "term": "Textual format" } ] } ], "note": null, "cmd": null } ], "toolType": [ "Library" ], "topic": [ { "uri": "http://edamontology.org/topic_2259", "term": "Systems biology" } ], "operatingSystem": [ "Linux", "Windows", "Mac" ], "language": [ "MATLAB", "C++", "Python" ], "license": "BSD-3-Clause", "collectionID": [], "maturity": "Mature", "cost": "Free of charge", "accessibility": "Open access", "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/AMICI-dev/AMICI/issues", "type": [ "Issue tracker" ], "note": null } ], "download": [], "documentation": [ { "url": "https://amici.readthedocs.io/en/latest/", "type": [ "User manual" ], "note": null } ], "publication": [ { "doi": "10.1093/bioinformatics/btab227", "pmid": "33821950", "pmcid": "PMC8545331", "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "AMICI: high-performance sensitivity analysis for large ordinary differential equation models", "abstract": "Ordinary differential equation models facilitate the understanding of cellular signal transduction and other biological processes. However, for large and comprehensive models, the computational cost of simulating or calibrating can be limiting. AMICI is a modular toolbox implemented in C++/Python/MATLAB that provides efficient simulation and sensitivity analysis routines tailored for scalable, gradient-based parameter estimation and uncertainty quantification.", "date": "2021-10-15T00:00:00Z", "citationCount": 37, "authors": [ { "name": "Frohlich F." }, { "name": "Weindl D." }, { "name": "Schalte Y." }, { "name": "Pathirana D." }, { "name": "Paszkowski L." }, { "name": "Lines G.T." }, { "name": "Stapor P." }, { "name": "Hasenauer J." } ], "journal": "Bioinformatics" } } ], "credit": [ { "name": "Fabian Fröhlich", "email": "fabian_froehlich@hms.harvard.edu", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact", "Maintainer", "Developer" ], "note": null }, { "name": "Jan Hasenauer", "email": "jan.hasenauer@uni-bonn.de", "url": null, "orcidid": "https://orcid.org/0000-0002-4935-3312", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null }, { "name": "Daniel Weindl", "email": "daniel.weindl@uni-bonn.de", "url": null, "orcidid": "https://orcid.org/0000-0001-9963-6057", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact", "Maintainer", "Developer" ], "note": null } ], "owner": "dweindl", "additionDate": "2019-09-28T12:06:10Z", "lastUpdate": "2025-05-08T07:28:52.817175Z", "editPermission": { "type": "private", "authors": [] }, "validated": 1, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "Galaxy Ecology", "description": "Galaxy Ecology is mainly developed by the French Data Terra research infrastructure Biodiversity data hub (PNDB). Its dedication is to provide tools for biodiversity data management and analysis for the Galaxy platform. Tools are useable through dedicated Galaxy instances hosted by Galaxy Europe (ecology.usegalaxy.eu) and Galaxy France (ecology.usegalaxy.fr).", "homepage": "https://github.com/galaxyecology/tools-ecology", "biotoolsID": "galaxy_ecology", "biotoolsCURIE": "biotools:galaxy_ecology", "version": [ "1.0.0" ], "otherID": [], "relation": [ { "biotoolsID": "galaxy", "type": "uses" }, { "biotoolsID": "tiaas", "type": "uses" }, { "biotoolsID": "Galaxy_Tools", "type": "uses" }, { "biotoolsID": "galaxy_france", "type": "includedIn" } ], "function": [], "toolType": [], "topic": [ { "uri": "http://edamontology.org/topic_3855", "term": "Environmental sciences" }, { "uri": "http://edamontology.org/topic_0610", "term": "Ecology" } ], "operatingSystem": [], "language": [], "license": "MIT", "collectionID": [], "maturity": "Mature", "cost": null, "accessibility": "Open access", "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://ecology.usegalaxy.eu", "type": [ "Galaxy service" ], "note": "European Galaxy Ecology instance" }, { "url": "https://ecology.usegalaxy.fr", "type": [ "Galaxy service" ], "note": "French Galaxy Ecology instance" } ], "download": [], "documentation": [], "publication": [ { "doi": "10.1093/gigascience/giae122", "pmid": null, "pmcid": null, "type": [ "Review" ], "version": null, "note": null, "metadata": { "title": "Guidance framework to apply best practices in ecological data analysis: lessons learned from building Galaxy-Ecology", "abstract": "Numerous conceptual frameworks exist for best practices in research data and analysis (e.g., Open Science and FAIR principles). In practice, there is a need for further progress to improve transparency, reproducibility, and confidence in ecology. Here, we propose a practical and operational framework for researchers and experts in ecology to achieve best practices for building analytical procedures from individual research projects to production-level analytical pipelines. We introduce the concept of atomization to identify analytical steps that support generalization by allowing us to go beyond single analyses. The term atomization is employed to convey the idea of single analytical steps as \"atoms\"composing an analytical procedure. When generalized, \"atoms\"can be used in more than a single case analysis. These guidelines were established during the development of the Galaxy-Ecology initiative, a web platform dedicated to data analysis in ecology. Galaxy-Ecology allows us to demonstrate a way to reach higher levels of reproducibility in ecological sciences by increasing the accessibility and reusability of analytical workflows once atomized and generalized.", "date": "2025-01-01T00:00:00Z", "citationCount": 0, "authors": [ { "name": "Royaux C." }, { "name": "Mihoub J.-B." }, { "name": "Josse M." }, { "name": "Pelletier D." }, { "name": "Norvez O." }, { "name": "Reecht Y." }, { "name": "Fouilloux A." }, { "name": "Rasche H." }, { "name": "Hiltemann S." }, { "name": "Batut B." }, { "name": "Marc E." }, { "name": "Seguineau P." }, { "name": "Masse G." }, { "name": "Amosse A." }, { "name": "Bissery C." }, { "name": "Lorrilliere R." }, { "name": "Martin A." }, { "name": "Bas Y." }, { "name": "Virgoulay T." }, { "name": "Chambon V." }, { "name": "Arnaud E." }, { "name": "Michon E." }, { "name": "Urfer C." }, { "name": "Trigodet E." }, { "name": "Delannoy M." }, { "name": "Lois G." }, { "name": "Julliard R." }, { "name": "Gruning B." }, { "name": "Le Bras Y." } ], "journal": "GigaScience" } } ], "credit": [ { "name": "Yvan Le Bras", "email": "yvan.le-bras@mnhn.fr", "url": null, "orcidid": "https://orcid.org/0000-0002-8504-068X", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null }, { "name": "Muséum national d'Histoire naturelle", "email": null, "url": null, "orcidid": null, "gridid": "grid.410350.3", "rorid": "03wkt5x30", "fundrefid": null, "typeEntity": "Institute", "typeRole": [], "note": null } ], "owner": "ylebras", "additionDate": "2025-05-07T12:50:07.458170Z", "lastUpdate": "2025-05-07T12:50:07.461506Z", "editPermission": { "type": "public", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "PIA - Protein Inference Algorithms", "description": "The main focus lays on the integrated inference algorithms, concluding the proteins from a set of identified spectra. But it also allows you to integrate results of various search engines, inspect your peptide spectrum matches, calculate FDR values across different results and visualize the correspondence between PSMs, peptides and proteins.", "homepage": "https://github.com/medbioinf/pia", "biotoolsID": "pia", "biotoolsCURIE": "biotools:pia", "version": [ "1.5" ], "otherID": [], "relation": [ { "biotoolsID": "knime", "type": "uses" } ], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3767", "term": "Protein identification" }, { "uri": "http://edamontology.org/operation_3649", "term": "Target-Decoy" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_0943", "term": "Mass spectrometry spectra" }, "format": [ { "uri": "http://edamontology.org/format_3713", "term": "Mascot .dat file" }, { "uri": "http://edamontology.org/format_3247", "term": "mzIdentML" }, { "uri": "http://edamontology.org/format_3475", "term": "TSV" }, { "uri": "http://edamontology.org/format_3684", "term": "PRIDE XML" }, { "uri": "http://edamontology.org/format_3711", "term": "X!Tandem XML" }, { "uri": "http://edamontology.org/format_3702", "term": "MSF" }, { "uri": "http://edamontology.org/format_3681", "term": "mzTab" } ] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_0945", "term": "Peptide identification" }, "format": [ { "uri": "http://edamontology.org/format_2206", "term": "Sequence feature table format (text)" }, { "uri": "http://edamontology.org/format_3765", "term": "KNIME datatable format" }, { "uri": "http://edamontology.org/format_3764", "term": "idXML" }, { "uri": "http://edamontology.org/format_3475", "term": "TSV" }, { "uri": "http://edamontology.org/format_3681", "term": "mzTab" }, { "uri": "http://edamontology.org/format_3247", "term": "mzIdentML" } ] }, { "data": { "uri": "http://edamontology.org/data_0989", "term": "Protein identifier" }, "format": [ { "uri": "http://edamontology.org/format_2206", "term": "Sequence feature table format (text)" }, { "uri": "http://edamontology.org/format_3765", "term": "KNIME datatable format" }, { "uri": "http://edamontology.org/format_3764", "term": "idXML" }, { "uri": "http://edamontology.org/format_3475", "term": "TSV" }, { "uri": "http://edamontology.org/format_3681", "term": "mzTab" }, { "uri": "http://edamontology.org/format_3247", "term": "mzIdentML" } ] } ], "note": "PIA allows you to inspect the results of common proteomics spectrum identification search engines, combine them seamlessly and conduct statistical analyses. The main focus of PIA lays on the integrated inference algorithms, i.e. concluding the proteins from a set of identified spectra. But it also allows you to inspect your peptide spectrum matches, calculate FDR values across different search engine results and visualize the correspondence between PSMs, peptides and proteins. Search engine results in several formats peptide spectrum matches (PSMs) and peptides Inferred Proteins", "cmd": null } ], "toolType": [ "Command-line tool", "Library", "Desktop application", "Workflow" ], "topic": [ { "uri": "http://edamontology.org/topic_0121", "term": "Proteomics" }, { "uri": "http://edamontology.org/topic_3520", "term": "Proteomics experiment" }, { "uri": "http://edamontology.org/topic_3120", "term": "Protein variants" } ], "operatingSystem": [ "Linux", "Windows", "Mac" ], "language": [ "Java" ], "license": "BSD-3-Clause", "collectionID": [ "KNIME", "de.NBI", "Proteomics", "BioInfra.Prot", "CUBiMed.RUB" ], "maturity": "Mature", "cost": "Free of charge", "accessibility": "Open access", "elixirPlatform": [], "elixirNode": [ "Germany" ], "elixirCommunity": [ "Proteomics" ], "link": [ { "url": "https://github.com/medbioinf/pia", "type": [ "Repository" ], "note": null } ], "download": [ { "url": "https://github.com/mpc-bioinformatics/pia", "type": "Source code", "note": null, "version": null }, { "url": "http://bioconda.github.io/recipes/pia/README.html", "type": "Software package", "note": null, "version": null }, { "url": "https://github.com/mpc-bioinformatics/pia/releases", "type": "Binaries", "note": null, "version": null }, { "url": "https://hub.docker.com/r/julianusz/pia", "type": "Container file", "note": null, "version": null } ], "documentation": [ { "url": "https://github.com/medbioinf/pia/wiki", "type": [ "General" ], "note": null } ], "publication": [ { "doi": "10.1021/acs.jproteome.5b00121", "pmid": "25938255", "pmcid": null, "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "PIA: An Intuitive Protein Inference Engine with a Web-Based User Interface", "abstract": "Protein inference connects the peptide spectrum matches (PSMs) obtained from database search engines back to proteins, which are typically at the heart of most proteomics studies. Different search engines yield different PSMs and thus different protein lists. Analysis of results from one or multiple search engines is often hampered by different data exchange formats and lack of convenient and intuitive user interfaces. We present PIA, a flexible software suite for combining PSMs from different search engine runs and turning these into consistent results. PIA can be integrated into proteomics data analysis workflows in several ways. A user-friendly graphical user interface can be run either locally or (e.g., for larger core facilities) from a central server. For automated data processing, stand-alone tools are available. PIA implements several established protein inference algorithms and can combine results from different search engines seamlessly. On several benchmark data sets, we show that PIA can identify a larger number of proteins at the same protein FDR when compared to that using inference based on a single search engine. PIA supports the majority of established search engines and data in the mzIdentML standard format. It is implemented in Java and freely available at https://github.com/mpc-bioinformatics/pia.", "date": "2015-07-02T00:00:00Z", "citationCount": 57, "authors": [ { "name": "Uszkoreit J." }, { "name": "Maerkens A." }, { "name": "Perez-Riverol Y." }, { "name": "Meyer H.E." }, { "name": "Marcus K." }, { "name": "Stephan C." }, { "name": "Kohlbacher O." }, { "name": "Eisenacher M." } ], "journal": "Journal of Proteome Research" } }, { "doi": "10.1021/acs.jproteome.8b00723", "pmid": "30474983", "pmcid": null, "type": [], "version": null, "note": null, "metadata": { "title": "Protein Inference Using PIA Workflows and PSI Standard File Formats", "abstract": "Proteomics using LC-MS/MS has become one of the main methods to analyze the proteins in biological samples in high-throughput. But the existing mass-spectrometry instruments are still limited with respect to resolution and measurable mass ranges, which is one of the main reasons why shotgun proteomics is the major approach. Here proteins are digested, which leads to the identification and quantification of peptides instead. While often neglected, the important step of protein inference needs to be conducted to infer from the identified peptides to the actual proteins in the original sample. In this work, we highlight some of the previously published and newly added features of the tool PIA - Protein Inference Algorithms, which helps the user with the protein inference of measured samples. We also highlight the importance of the usage of PSI standard file formats, as PIA is the only current software supporting all available standards used for spectrum identification and protein inference. Additionally, we briefly describe the benefits of working with workflow environments for proteomics analyses and show the new features of the PIA nodes for the KNIME Analytics Platform. Finally, we benchmark PIA against a recently published data set for isoform detection. PIA is open source and available for download on GitHub (https://github.com/mpc-bioinformatics/pia) or directly via the community extensions inside the KNIME analytics platform.", "date": "2019-02-01T00:00:00Z", "citationCount": 30, "authors": [ { "name": "Uszkoreit J." }, { "name": "Perez-Riverol Y." }, { "name": "Eggers B." }, { "name": "Marcus K." }, { "name": "Eisenacher M." } ], "journal": "Journal of Proteome Research" } } ], "credit": [ { "name": "Julian Uszkoreit", "email": "julian.uszkoreit@rub.de", "url": null, "orcidid": "http://orcid.org/0000-0001-7522-4007", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact", "Developer", "Maintainer" ], "note": null }, { "name": "CUBiMed.RUB", "email": "cubimed@rub.de", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Institute", "typeRole": [ "Provider" ], "note": null } ], "owner": "julianu", "additionDate": "2016-07-12T10:54:05Z", "lastUpdate": "2025-05-02T13:15:26.717477Z", "editPermission": { "type": "private", "authors": [] }, "validated": 1, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "StripePy", "description": "StripePy recognizes architectural stripes in 3C and Hi-C contact maps using geometric reasoning", "homepage": "https://github.com/paulsengroup/StripePy", "biotoolsID": "stripepy", "biotoolsCURIE": "biotools:stripepy", "version": [ "0.0.1", "0.0.2", "1.0.0", "1.1.0" ], "otherID": [], "relation": [], "function": [], "toolType": [ "Command-line tool" ], "topic": [ { "uri": "http://edamontology.org/topic_0091", "term": "Bioinformatics" } ], "operatingSystem": [ "Linux", "Mac", "Windows" ], "language": [ "Python" ], "license": "MIT", "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/paulsengroup/StripePy/issues", "type": [ "Issue tracker" ], "note": null }, { "url": "https://github.com/paulsengroup/StripePy/discussions", "type": [ "Discussion forum" ], "note": null }, { "url": "https://github.com/paulsengroup/StripePy.git", "type": [ "Repository" ], "note": null } ], "download": [ { "url": "https://github.com/paulsengroup/StripePy/releases", "type": "Source code", "note": null, "version": null }, { "url": "https://hub.docker.com/r/paulsengroup/stripepy", "type": "Container file", "note": null, "version": null }, { "url": "https://doi.org/10.5281/zenodo.14283921", "type": "Test data", "note": null, "version": null }, { "url": "https://pypi.org/project/stripepy-hic/", "type": "Binaries", "note": null, "version": null }, { "url": "https://anaconda.org/bioconda/stripepy-hic", "type": "Binaries", "note": null, "version": null } ], "documentation": [ { "url": "https://github.com/paulsengroup/StripePy/blob/main/README.md", "type": [ "User manual" ], "note": null } ], "publication": [ { "doi": "10.1101/2024.12.20.629789", "pmid": null, "pmcid": null, "type": [], "version": null, "note": null, "metadata": null } ], "credit": [], "owner": "robomics", "additionDate": "2024-12-21T15:24:55.662209Z", "lastUpdate": "2025-05-02T11:01:00.332596Z", "editPermission": { "type": "group", "authors": [ "rea1991" ] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "epimutacions", "description": "The package includes some statistical outlier detection methods for epimutations detection in DNA methylation data. The methods included in the package are MANOVA, Multivariate linear models, isolation forest, robust mahalanobis distance, quantile and beta. The methods compare a case sample with a suspected disease against a reference panel (composed of healthy individuals) to identify epimutations in the given case sample. It also contains functions to annotate and visualize the identified epimutations.", "homepage": "https://www.bioconductor.org/packages/release/bioc/html/epimutacions.html", "biotoolsID": "epimutacions", "biotoolsCURIE": "biotools:epimutacions", "version": [ "1.2.0" ], "otherID": [], "relation": [], "function": [], "toolType": [], "topic": [ { "uri": "http://edamontology.org/topic_3295", "term": "Epigenetics" } ], "operatingSystem": [], "language": [], "license": null, "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://www.bioconductor.org/packages/epimutacions", "type": [ "Mirror" ], "note": null } ], "download": [ { "url": "https://www.bioconductor.org/packages/release/bioc/src/contrib/epimutacions_1.2.0.tar.gz", "type": "Source code", "note": null, "version": "1.2.0" } ], "documentation": [ { "url": "https://www.bioconductor.org/packages/release/bioc/manuals/epimutacions/man/epimutacions.pdf", "type": [ "API documentation" ], "note": null }, { "url": "https://www.bioconductor.org/packages/release/bioc/vignettes/epimutacions/inst/doc/epimutacions.html", "type": [ "User manual" ], "note": null } ], "publication": [ { "doi": "10.1080/15592294.2023.2230670", "pmid": "37409354", "pmcid": "PMC10327521", "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "Epimutation detection in the clinical context: guidelines and a use case from a new Bioconductor package", "abstract": "Epimutations are rare alterations of the normal DNA methylation pattern at specific loci, which can lead to rare diseases. Methylation microarrays enable genome-wide epimutation detection, but technical limitations prevent their use in clinical settings: methods applied to rare diseases’ data cannot be easily incorporated to standard analyses pipelines, while epimutation methods implemented in R packages (ramr) have not been validated for rare diseases. We have developed epimutacions, a Bioconductor package (https://bioconductor.org/packages/release/bioc/html/epimutacions.html). epimutacions implements two previously reported methods and four new statistical approaches to detect epimutations, along with functions to annotate and visualize epimutations. Additionally, we have developed an user-friendly Shiny app to facilitate epimutations detection (https://github.com/isglobal-brge/epimutacionsShiny) to non-bioinformatician users. We first compared the performance of epimutacions and ramr packages using three public datasets with experimentally validated epimutations. Methods in epimutacions had a high performance at low sample sizes and outperformed methods in ramr. Second, we used two general population children cohorts (INMA and HELIX) to determine the technical and biological factors that affect epimutations detection, providing guidelines on how designing the experiments or preprocessing the data. In these cohorts, most epimutations did not correlate with detectable regional gene expression changes. Finally, we exemplified how epimutacions can be used in a clinical context. We run epimutacions in a cohort of children with autism disorder and identified novel recurrent epimutations in candidate genes for autism. Overall, we present epimutacions a new Bioconductor package for incorporating epimutations detection to rare disease diagnosis and provide guidelines for the design and data analyses.", "date": "2023-01-01T00:00:00Z", "citationCount": 0, "authors": [ { "name": "Ruiz-Arenas C." }, { "name": "Abarrategui L." }, { "name": "Hernandez-Ferrer C." }, { "name": "Escriba-Montagut X." }, { "name": "Pelegri-Siso D." }, { "name": "Ryser-Welch P." }, { "name": "Vrijheid M." }, { "name": "Bustamante M." }, { "name": "Grazuleviciene R." }, { "name": "Lepeule J." }, { "name": "Mathai M." }, { "name": "Vafeiadi M." }, { "name": "Beltran S." }, { "name": "Perez-Jurado L.A." }, { "name": "Gonzalez J.R." } ], "journal": "Epigenetics" } } ], "credit": [ { "name": "Carlos Ruiz-Arenas", "email": "carlos.ruiz@isglobal.org", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Developer" ], "note": null }, { "name": "Leire Abarrategui", "email": "leire.abarrategui@isglobal.org", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Developer" ], "note": null }, { "name": "Carles Hernandez-Ferrer", "email": "carles.hernandez@isglobal.org", "url": "http://www.carleshf.com", "orcidid": "https://orcid.org/0000-0002-8029-7160", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": null, "typeRole": [], "note": null }, { "name": "Dolors Pelegri-Siso", "email": "dolors.pelegri@isglobal.org", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Maintainer" ], "note": null }, { "name": "Juan R. Gonzalez", "email": "juanr.gonzalez@isglobal.org", "url": "https://brge.isglobal.org/", "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": null, "typeRole": [], "note": null } ], "owner": "chernan3", "additionDate": "2023-02-07T14:25:10.924789Z", "lastUpdate": "2025-05-01T22:27:05.714967Z", "editPermission": { "type": "public", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "We-expose", "description": "The WE-EXPOSE (Working Life Exposome for Policy, OSH and Science) Toolbox makes available tools developed in the EU EPHOR project for different stakeholders focused on: innovative methods and improved knowledge.", "homepage": "https://www.we-expose.eu/", "biotoolsID": "we-expose", "biotoolsCURIE": "biotools:we-expose", "version": [ "1.0" ], "otherID": [], "relation": [], "function": [], "toolType": [], "topic": [], "operatingSystem": [], "language": [], "license": null, "collectionID": [ "EHEN" ], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "eelco", "additionDate": "2025-04-17T13:14:18.531116Z", "lastUpdate": "2025-05-01T14:22:20.034579Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "EUCAIM Wizard Tool", "description": "The EUCAIM Wizard Tool performs an analysis of data re-identification risks of imaging and clinical data that follow the EUCAIM CDM. It includes and uses an EUCAIM specific configuration of the ARX Data Anonymization Tool (biotools:arx) for further anonymization, by supporting a wide variety of privacy and risk models as well methods for analyzing the usefulness of output data.", "homepage": "https://harbor.eucaim.cancerimage.eu/harbor/", "biotoolsID": "eucaim_wizard_tool", "biotoolsCURIE": "biotools:eucaim_wizard_tool", "version": [ "beta1.0" ], "otherID": [], "relation": [ { "biotoolsID": "arx", "type": "includes" }, { "biotoolsID": "arx", "type": "uses" } ], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3283", "term": "Anonymisation" } ], "input": [], "output": [], "note": null, "cmd": null } ], "toolType": [], "topic": [], "operatingSystem": [], "language": [], "license": null, "collectionID": [ "EUCAIM" ], "maturity": null, "cost": null, "accessibility": "Open access (with restrictions)", "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/goharbor/harbor", "type": [ "Repository" ], "note": null } ], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "vkalokyri", "additionDate": "2025-04-30T10:28:37.002350Z", "lastUpdate": "2025-05-01T12:43:46.544425Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "OpenMS", "description": "Open source library and a collection of tools and interfaces for the analysis of mass spectrometry data. Includes over 200 standalone (TOPP) tools that can be combined to a workflow with the integrated workflow editor TOPPAS. Raw and intermediate mass spectrometry data can be visualised with the included viewer TOPPView.", "homepage": "http://www.openms.de", "biotoolsID": "openms", "biotoolsCURIE": "biotools:openms", "version": [ "2.0.0" ], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3767", "term": "Protein identification" }, { "uri": "http://edamontology.org/operation_1812", "term": "Parsing" }, { "uri": "http://edamontology.org/operation_2409", "term": "Data handling" }, { "uri": "http://edamontology.org/operation_3628", "term": "Chromatographic alignment" }, { "uri": "http://edamontology.org/operation_3627", "term": "Mass spectra calibration" }, { "uri": "http://edamontology.org/operation_0335", "term": "Formatting" }, { "uri": "http://edamontology.org/operation_3630", "term": "Protein quantification" }, { "uri": "http://edamontology.org/operation_3633", "term": "Retention time prediction" }, { "uri": "http://edamontology.org/operation_0226", "term": "Annotation" }, { "uri": "http://edamontology.org/operation_3092", "term": "Protein feature detection" }, { "uri": "http://edamontology.org/operation_3705", "term": "Isotope-coded protein label" }, { "uri": "http://edamontology.org/operation_3634", "term": "Label-free quantification" }, { "uri": "http://edamontology.org/operation_3639", "term": "iTRAQ" }, { "uri": "http://edamontology.org/operation_3631", "term": "Peptide identification" }, { "uri": "http://edamontology.org/operation_3215", "term": "Peak detection" }, { "uri": "http://edamontology.org/operation_3694", "term": "Mass spectrum visualisation" }, { "uri": "http://edamontology.org/operation_3635", "term": "Labeled quantification" }, { "uri": "http://edamontology.org/operation_3359", "term": "Splitting" }, { "uri": "http://edamontology.org/operation_3214", "term": "Spectral analysis" }, { "uri": "http://edamontology.org/operation_3629", "term": "Deisotoping" }, { "uri": "http://edamontology.org/operation_3649", "term": "Target-Decoy" }, { "uri": "http://edamontology.org/operation_3023", "term": "Prediction and recognition (protein)" }, { "uri": "http://edamontology.org/operation_2424", "term": "Comparison" }, { "uri": "http://edamontology.org/operation_3435", "term": "Standardisation and normalisation" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_2536", "term": "Mass spectrometry data" }, "format": [ { "uri": "http://edamontology.org/format_3655", "term": "pepXML" }, { "uri": "http://edamontology.org/format_3248", "term": "mzQuantML" }, { "uri": "http://edamontology.org/format_3652", "term": "dta" }, { "uri": "http://edamontology.org/format_1929", "term": "FASTA" }, { "uri": "http://edamontology.org/format_3747", "term": "protXML" }, { "uri": "http://edamontology.org/format_3764", "term": "idXML" }, { "uri": "http://edamontology.org/format_2549", "term": "OBO" }, { "uri": "http://edamontology.org/format_2332", "term": "XML" }, { "uri": "http://edamontology.org/format_3246", "term": "TraML" }, { "uri": "http://edamontology.org/format_3244", "term": "mzML" }, { "uri": "http://edamontology.org/format_3247", "term": "mzIdentML" }, { "uri": "http://edamontology.org/format_3654", "term": "mzXML" }, { "uri": "http://edamontology.org/format_3651", "term": "MGF" }, { "uri": "http://edamontology.org/format_3683", "term": "qcML" } ] }, { "data": { "uri": "http://edamontology.org/data_0849", "term": "Sequence record" }, "format": [ { "uri": "http://edamontology.org/format_3655", "term": "pepXML" }, { "uri": "http://edamontology.org/format_3248", "term": "mzQuantML" }, { "uri": "http://edamontology.org/format_3652", "term": "dta" }, { "uri": "http://edamontology.org/format_1929", "term": "FASTA" }, { "uri": "http://edamontology.org/format_3747", "term": "protXML" }, { "uri": "http://edamontology.org/format_3764", "term": "idXML" }, { "uri": "http://edamontology.org/format_2549", "term": "OBO" }, { "uri": "http://edamontology.org/format_2332", "term": "XML" }, { "uri": "http://edamontology.org/format_3246", "term": "TraML" }, { "uri": "http://edamontology.org/format_3244", "term": "mzML" }, { "uri": "http://edamontology.org/format_3247", "term": "mzIdentML" }, { "uri": "http://edamontology.org/format_3654", "term": "mzXML" }, { "uri": "http://edamontology.org/format_3651", "term": "MGF" }, { "uri": "http://edamontology.org/format_3683", "term": "qcML" } ] }, { "data": { "uri": "http://edamontology.org/data_0945", "term": "Peptide identification" }, "format": [ { "uri": "http://edamontology.org/format_3655", "term": "pepXML" }, { "uri": "http://edamontology.org/format_3248", "term": "mzQuantML" }, { "uri": "http://edamontology.org/format_3652", "term": "dta" }, { "uri": "http://edamontology.org/format_1929", "term": "FASTA" }, { "uri": "http://edamontology.org/format_3747", "term": "protXML" }, { "uri": "http://edamontology.org/format_3764", "term": "idXML" }, { "uri": "http://edamontology.org/format_2549", "term": "OBO" }, { "uri": "http://edamontology.org/format_2332", "term": "XML" }, { "uri": "http://edamontology.org/format_3246", "term": "TraML" }, { "uri": "http://edamontology.org/format_3244", "term": "mzML" }, { "uri": "http://edamontology.org/format_3247", "term": "mzIdentML" }, { "uri": "http://edamontology.org/format_3654", "term": "mzXML" }, { "uri": "http://edamontology.org/format_3651", "term": "MGF" }, { "uri": "http://edamontology.org/format_3683", "term": "qcML" } ] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_0945", "term": "Peptide identification" }, "format": [ { "uri": "http://edamontology.org/format_3655", "term": "pepXML" }, { "uri": "http://edamontology.org/format_3248", "term": "mzQuantML" }, { "uri": "http://edamontology.org/format_3652", "term": "dta" }, { "uri": "http://edamontology.org/format_1929", "term": "FASTA" }, { "uri": "http://edamontology.org/format_3764", "term": "idXML" }, { "uri": "http://edamontology.org/format_3654", "term": "mzXML" }, { "uri": "http://edamontology.org/format_3246", "term": "TraML" }, { "uri": "http://edamontology.org/format_3244", "term": "mzML" }, { "uri": "http://edamontology.org/format_3247", "term": "mzIdentML" }, { "uri": "http://edamontology.org/format_3651", "term": "MGF" }, { "uri": "http://edamontology.org/format_3683", "term": "qcML" } ] }, { "data": { "uri": "http://edamontology.org/data_2603", "term": "Expression data" }, "format": [ { "uri": "http://edamontology.org/format_3655", "term": "pepXML" }, { "uri": "http://edamontology.org/format_3248", "term": "mzQuantML" }, { "uri": "http://edamontology.org/format_3652", "term": "dta" }, { "uri": "http://edamontology.org/format_1929", "term": "FASTA" }, { "uri": "http://edamontology.org/format_3764", "term": "idXML" }, { "uri": "http://edamontology.org/format_3654", "term": "mzXML" }, { "uri": "http://edamontology.org/format_3246", "term": "TraML" }, { "uri": "http://edamontology.org/format_3244", "term": "mzML" }, { "uri": "http://edamontology.org/format_3247", "term": "mzIdentML" }, { "uri": "http://edamontology.org/format_3651", "term": "MGF" }, { "uri": "http://edamontology.org/format_3683", "term": "qcML" } ] } ], "note": null, "cmd": null } ], "toolType": [ "Library", "Workbench" ], "topic": [ { "uri": "http://edamontology.org/topic_3520", "term": "Proteomics experiment" }, { "uri": "http://edamontology.org/topic_0121", "term": "Proteomics" }, { "uri": "http://edamontology.org/topic_3172", "term": "Metabolomics" } ], "operatingSystem": [ "Linux", "Windows", "Mac" ], "language": [ "C++" ], "license": "BSD-3-Clause", "collectionID": [ "KNIME", "de.NBI", "Proteomics", "OpenMS" ], "maturity": "Mature", "cost": "Free of charge", "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/OpenMS/OpenMS", "type": [ "Repository" ], "note": null } ], "download": [ { "url": "https://github.com/OpenMS/OpenMS", "type": "Source code", "note": null, "version": null }, { "url": "http://sourceforge.net/projects/open-ms/files/OpenMS/OpenMS-2.0/", "type": "Binaries", "note": null, "version": null }, { "url": "https://github.com/OpenMS/OpenMS", "type": "Source code", "note": null, "version": null } ], "documentation": [ { "url": "http://ftp.mi.fu-berlin.de/pub/OpenMS/release-documentation/html/index.html", "type": [ "General" ], "note": null } ], "publication": [ { "doi": "10.1038/nmeth.3959", "pmid": "27575624", "pmcid": null, "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "OpenMS: A flexible open-source software platform for mass spectrometry data analysis", "abstract": "© 2016 Nature America, Inc. All rights reserved.High-resolution mass spectrometry (MS) has become an important tool in the life sciences, contributing to the diagnosis and understanding of human diseases, elucidating biomolecular structural information and characterizing cellular signaling networks. However, the rapid growth in the volume and complexity of MS data makes transparent, accurate and reproducible analysis difficult. We present OpenMS 2.0 (http://www.openms.de), a robust, open-source, cross-platform software specifically designed for the flexible and reproducible analysis of high-throughput MS data. The extensible OpenMS software implements common mass spectrometric data processing tasks through a well-defined application programming interface in C++ and Python and through standardized open data formats. OpenMS additionally provides a set of 185 tools and ready-made workflows for common mass spectrometric data processing tasks, which enable users to perform complex quantitative mass spectrometric analyses with ease.", "date": "2016-08-30T00:00:00Z", "citationCount": 246, "authors": [ { "name": "Rost H.L." }, { "name": "Sachsenberg T." }, { "name": "Aiche S." }, { "name": "Bielow C." }, { "name": "Weisser H." }, { "name": "Aicheler F." }, { "name": "Andreotti S." }, { "name": "Ehrlich H.-C." }, { "name": "Gutenbrunner P." }, { "name": "Kenar E." }, { "name": "Liang X." }, { "name": "Nahnsen S." }, { "name": "Nilse L." }, { "name": "Pfeuffer J." }, { "name": "Rosenberger G." }, { "name": "Rurik M." }, { "name": "Schmitt U." }, { "name": "Veit J." }, { "name": "Walzer M." }, { "name": "Wojnar D." }, { "name": "Wolski W.E." }, { "name": "Schilling O." }, { "name": "Choudhary J.S." }, { "name": "Malmstrom L." }, { "name": "Aebersold R." }, { "name": "Reinert K." }, { "name": "Kohlbacher O." } ], "journal": "Nature Methods" } }, { "doi": "10.1007/978-1-60761-987-1_23", "pmid": null, "pmcid": null, "type": [ "Other" ], "version": null, "note": null, "metadata": { "title": "OpenMS and TOPP: open source software for LC-MS data analysis.", "abstract": "Proteomics experiments based on state-of-the-art mass spectrometry produce vast amounts of data, which cannot be analyzed manually. Hence, software is needed which is able to analyze the data in an automated fashion. The need for robust and reusable software tools triggered the development of libraries implementing different algorithms for the various analysis steps. OpenMS is such a software library and provides a wealth of data structures and algorithms for the analysis of mass spectrometric data. For users unfamiliar with programming, TOPP (\"The OpenMS Proteomics Pipeline\") offers a wide range of already implemented tools sharing the same interface and designed for a specific analysis task each. TOPP thus makes the sophisticated algorithms of OpenMS accessible to nonprogrammers. The individual TOPP tools can be strung together into pipelines for analyzing mass spectrometry-based experiments starting from the raw output of the mass spectrometer. These analysis pipelines can be constructed using a graphical editor. Even complex analytical workflows can thus be analyzed with ease.", "date": "2011-01-01T00:00:00Z", "citationCount": 65, "authors": [ { "name": "Bertsch A." }, { "name": "Gropl C." }, { "name": "Reinert K." }, { "name": "Kohlbacher O." } ], "journal": "Methods in molecular biology (Clifton, N.J.)" } } ], "credit": [ { "name": "ETH Zürich", "email": null, "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Institute", "typeRole": [ "Provider" ], "note": null }, { "name": "Eberhard-Karls-Universität Tübingen", "email": null, "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Institute", "typeRole": [ "Provider" ], "note": null }, { "name": "Freie Universität Berlin", "email": null, "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Institute", "typeRole": [ "Provider" ], "note": null }, { "name": "Center for Integrative Bioinformatics (CiBi)", "email": null, "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Consortium", "typeRole": [], "note": null }, { "name": "cibi", "email": null, "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Institute", "typeRole": [ "Provider" ], "note": null }, { "name": "General Mailinglist", "email": "open-ms-general@lists.sourceforge.net", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": null, "typeRole": [ "Support" ], "note": null }, { "name": "General Mailinglist", "email": "open-ms-general@lists.sourceforge.net", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null }, { "name": "Hannes Röst", "email": null, "url": null, "orcidid": "http://orcid.org/0000-0003-0990-7488", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Contributor" ], "note": null } ], "owner": "samwein", "additionDate": "2016-01-19T16:39:56Z", "lastUpdate": "2025-04-30T11:39:30.251890Z", "editPermission": { "type": "group", "authors": [ "proteomics.bio.tools" ] }, "validated": 1, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "pyOpenMS", "description": "Python library for mass spectrometry, specifically for the analysis of proteomics and metabolomics data.", "homepage": "https://github.com/OpenMS/pyopenms-extra/blob/master/docs/source/index.rst", "biotoolsID": "pyOpenMS", "biotoolsCURIE": "biotools:pyOpenMS", "version": [], "otherID": [], "relation": [], "function": [], "toolType": [ "Library" ], "topic": [ { "uri": "http://edamontology.org/topic_0121", "term": "Proteomics" }, { "uri": "http://edamontology.org/topic_3520", "term": "Proteomics experiment" }, { "uri": "http://edamontology.org/topic_0601", "term": "Protein modifications" } ], "operatingSystem": [ "Linux", "Windows", "Mac" ], "language": [ "Python" ], "license": "BSD-3-Clause", "collectionID": [], "maturity": "Mature", "cost": "Free of charge", "accessibility": "Open access", "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/OpenMS/pyopenms-extra", "type": [ "Repository" ], "note": null }, { "url": "https://github.com/OpenMS/pyopenms-extra/issues", "type": [ "Issue tracker" ], "note": null } ], "download": [], "documentation": [ { "url": "https://pyopenms.readthedocs.io", "type": [ "User manual" ], "note": null } ], "publication": [ { "doi": "10.7287/PEERJ.PREPRINTS.27736", "pmid": null, "pmcid": null, "type": [ "Primary" ], "version": null, "note": null, "metadata": null } ], "credit": [ { "name": "Hannes L. Rost", "email": "hannes.rost@utoronto.ca", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null } ], "owner": "samwein", "additionDate": "2019-08-09T13:16:33Z", "lastUpdate": "2025-04-30T11:39:29.549782Z", "editPermission": { "type": "private", "authors": [] }, "validated": 1, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "OpenSWATH", "description": "OpenSWATH is a proteomics software that allows analysis of LC-MS/MS DIA (data independent acquisition) and implemented as part of OpenMS.", "homepage": "http://www.openswath.org", "biotoolsID": "OpenSWATH", "biotoolsCURIE": "biotools:OpenSWATH", "version": [ "OpenMS 2.4.0" ], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_0335", "term": "Formatting" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_3108", "term": "Experimental measurement" }, "format": [ { "uri": "http://edamontology.org/format_3710", "term": "WIFF format" }, { "uri": "http://edamontology.org/format_3245", "term": "Mass spectrometry data format" } ] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_2536", "term": "Mass spectrometry data" }, "format": [ { "uri": "http://edamontology.org/format_3244", "term": "mzML" }, { "uri": "http://edamontology.org/format_3621", "term": "SQLite format" }, { "uri": "http://edamontology.org/format_3654", "term": "mzXML" } ] } ], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_3215", "term": "Peak detection" }, { "uri": "http://edamontology.org/operation_3628", "term": "Chromatographic alignment" }, { "uri": "http://edamontology.org/operation_3203", "term": "Chromatogram visualisation" }, { "uri": "http://edamontology.org/operation_3649", "term": "Target-Decoy" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_2536", "term": "Mass spectrometry data" }, "format": [ { "uri": "http://edamontology.org/format_3244", "term": "mzML" }, { "uri": "http://edamontology.org/format_3621", "term": "SQLite format" }, { "uri": "http://edamontology.org/format_3654", "term": "mzXML" } ] }, { "data": { "uri": "http://edamontology.org/data_0943", "term": "Mass spectrometry spectra" }, "format": [ { "uri": "http://edamontology.org/format_3475", "term": "TSV" }, { "uri": "http://edamontology.org/format_3246", "term": "TraML" } ] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_0944", "term": "Peptide mass fingerprint" }, "format": [ { "uri": "http://edamontology.org/format_3833", "term": "featureXML" }, { "uri": "http://edamontology.org/format_3475", "term": "TSV" }, { "uri": "http://edamontology.org/format_3621", "term": "SQLite format" } ] } ], "note": null, "cmd": null } ], "toolType": [ "Command-line tool" ], "topic": [ { "uri": "http://edamontology.org/topic_0121", "term": "Proteomics" }, { "uri": "http://edamontology.org/topic_3520", "term": "Proteomics experiment" } ], "operatingSystem": [ "Linux", "Windows", "Mac" ], "language": [ "C++" ], "license": "BSD-3-Clause", "collectionID": [ "ms-utils", "Proteomics" ], "maturity": null, "cost": "Free of charge", "accessibility": "Open access", "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/OpenSWATH/docker", "type": [ "Repository" ], "note": null }, { "url": "https://github.com/OpenMS/OpenMS", "type": [ "Repository" ], "note": null }, { "url": "https://sourceforge.net/projects/open-ms/lists/open-ms-general", "type": [ "Mailing list" ], "note": null } ], "download": [ { "url": "http://www.openswath.org/en/latest/docs/binaries.html", "type": "Software package", "note": null, "version": null }, { "url": "http://www.openswath.org/en/latest/docs/sources.html", "type": "Source code", "note": null, "version": null } ], "documentation": [ { "url": "https://buildmedia.readthedocs.org/media/pdf/openswath/latest/openswath.pdf", "type": [ "User manual" ], "note": null } ], "publication": [ { "doi": null, "pmid": "24727770", "pmcid": null, "type": [], "version": null, "note": null, "metadata": { "title": "OpenSWATH enables automated, targeted analysis of data-independent acquisition MS data", "abstract": "", "date": "2014-01-01T00:00:00Z", "citationCount": 409, "authors": [ { "name": "Rost H.L." }, { "name": "Rosenberger G." }, { "name": "Navarro P." }, { "name": "Gillet L." }, { "name": "Miladinovia S.M." }, { "name": "Schubert O.T." }, { "name": "Wolski W." }, { "name": "Collins B.C." }, { "name": "Malmstrom J." }, { "name": "Malmstrom L." }, { "name": "Aebersold R." } ], "journal": "Nature Biotechnology" } } ], "credit": [ { "name": "Hannes Röst", "email": "hroest@stanford.edu", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [], "note": null }, { "name": "George Rosenberger", "email": "gr2578@cumc.columbia.edu", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [], "note": null } ], "owner": "samwein", "additionDate": "2019-06-18T11:06:01Z", "lastUpdate": "2025-04-30T11:39:29.102190Z", "editPermission": { "type": "private", "authors": [] }, "validated": 1, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "OpenPepXL", "description": "An Open-Source Tool for Sensitive Identification of Cross-Linked Peptides in XL-MS.\n\nProtein-Protein Cross-Linking (OpenPepXL) – OpenMS.\n\nOpenPepXL is a protein-protein cross-link identification tool implemented in C++ as part of OpenMS. It works with all uncleavable labeled and label-free cross-linkers but not (yet) with cleavable ones.", "homepage": "https://openms.org/openpepxl", "biotoolsID": "openpepxl", "biotoolsCURIE": "biotools:openpepxl", "version": [], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3631", "term": "Peptide identification" }, { "uri": "http://edamontology.org/operation_3629", "term": "Deisotoping" }, { "uri": "http://edamontology.org/operation_3767", "term": "Protein identification" }, { "uri": "http://edamontology.org/operation_3431", "term": "Deposition" } ], "input": [], "output": [], "note": null, "cmd": null } ], "toolType": [ "Command-line tool" ], "topic": [ { "uri": "http://edamontology.org/topic_3520", "term": "Proteomics experiment" }, { "uri": "http://edamontology.org/topic_0154", "term": "Small molecules" }, { "uri": "http://edamontology.org/topic_0121", "term": "Proteomics" } ], "operatingSystem": [], "language": [], "license": "BSD-3-Clause", "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://www.openms.de/openpepxl", "type": [ "Other" ], "note": null } ], "download": [], "documentation": [], "publication": [ { "doi": "10.1074/MCP.TIR120.002186", "pmid": "33067342", "pmcid": "PMC7710140", "type": [], "version": null, "note": null, "metadata": { "title": "OpenPepXL: An Open-Source Tool for Sensitive Identification of Cross-Linked Peptides in XL-MS", "abstract": "© 2020 Netz et al. Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.Cross-linking MS (XL-MS) has been recognized as an effective source of information about protein structures and interactions. In contrast to regular peptide identification, XL-MS has to deal with a quadratic search space, where peptides from every protein could potentially be cross-linked to any other protein. To cope with this search space, most tools apply different heuristics for search space reduction. We introduce a new open-source XL-MS database search algorithm, OpenPepXL, which offers increased sensitivity compared with other tools. OpenPepXL searches the full search space of an XL-MS experiment without using heuristics to reduce it. Because of efficient data structures and built-in parallelization OpenPepXL achieves excellent runtimes and can also be deployed on large compute clusters and cloud services while maintaining a slim memory footprint. We compared OpenPepXL to several other commonly used tools for identification of noncleavable labeled and label-free cross-linkers on a diverse set of XL-MS experiments. In our first comparison, we used a data set from a fraction of a cell lysate with a protein database of 128 targets and 128 decoys. At 5% FDR, OpenPepXL finds from 7% to over 50% more unique residue pairs (URPs) than other tools. On data sets with available high-resolution structures for cross-link validation OpenPepXL reports from 7% to over 40% more structurally validated URPs than other tools. Additionally, we used a synthetic peptide data set that allows objective validation of cross-links without relying on structural information and found that OpenPepXL reports at least 12% more validated URPs than other tools. It has been built as part of the OpenMS suite of tools and supports Windows, macOS, and Linux operating systems. OpenPepXL also supports the MzIdentML 1.2 format for XL-MS identification results. It is freely available under a three-clause BSD license at https://openms.org/openpepxl.", "date": "2020-12-01T00:00:00Z", "citationCount": 0, "authors": [ { "name": "Netz E." }, { "name": "Dijkstra T.M.H." }, { "name": "Sachsenberg T." }, { "name": "Zimmermann L." }, { "name": "Walzer M." }, { "name": "Monecke T." }, { "name": "Ficner R." }, { "name": "Dybkov O." }, { "name": "Urlaub H." }, { "name": "Kohlbacher O." } ], "journal": "Molecular and Cellular Proteomics" } } ], "credit": [ { "name": "Eugen Netz", "email": "eugen.netz@tuebingen.mpg.de", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [], "note": null }, { "name": "Oliver Kohlbacher", "email": "oliver.kohlbacher@uni-tuebingen.de", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [], "note": null } ], "owner": "samwein", "additionDate": "2021-01-18T11:10:26Z", "lastUpdate": "2025-04-30T11:39:28.349250Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": "tool" }, { "name": "FLASHIda", "description": "FLASHIda is an intelligent online data acquisition algorithm for top-down proteomics (TDP) that ensures the real-time selection of high-quality precursors of diverse proteoforms. FLASHIda combines fast decharging algorithms in FLASHDeconv and machine learning-based quality assessment to identify optimal precursors for fragmentation. Currently the C# source code and instruction of FLASHIda is available in here under a BSD three-clause license. We are working on merging FLASHIda into OpenMS.", "homepage": "https://www.openms.org/applications/flashida/", "biotoolsID": "flashida", "biotoolsCURIE": "biotools:flashida", "version": [], "otherID": [], "relation": [], "function": [], "toolType": [], "topic": [], "operatingSystem": [], "language": [], "license": null, "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "samwein", "additionDate": "2023-09-30T19:54:03.880432Z", "lastUpdate": "2025-04-30T11:39:18.106379Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "FLASHIda", "description": "FLASHIda is an intelligent online data acquisition algorithm for top-down proteomics (TDP) that ensures the real-time selection of high-quality precursors of diverse proteoforms. FLASHIda combines fast decharging algorithms in FLASHDeconv and machine learning-based quality assessment to identify optimal precursors for fragmentation. Currently the C# source code and instruction of FLASHIda is available in here under a BSD three-clause license. We are working on merging FLASHIda into OpenMS.", "homepage": "https://www.openms.org/applications/flashida/", "biotoolsID": "flashida2", "biotoolsCURIE": "biotools:flashida2", "version": [], "otherID": [], "relation": [], "function": [], "toolType": [], "topic": [], "operatingSystem": [], "language": [], "license": null, "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "samwein", "additionDate": "2023-09-30T19:58:13.012473Z", "lastUpdate": "2025-04-30T11:39:17.046987Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "BioSurfDB", "description": "BioSurfDB is a online database for biodegradation and biosurfactants.", "homepage": "https://www.biosurfdb.org", "biotoolsID": "biosurfdb", "biotoolsCURIE": "biotools:biosurfdb", "version": [], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_0495", "term": "Local alignment" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_3494", "term": "DNA sequence" }, "format": [] }, { "data": { "uri": "http://edamontology.org/data_2886", "term": "Protein sequence record" }, "format": [] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_1383", "term": "Nucleic acid sequence alignment" }, "format": [] }, { "data": { "uri": "http://edamontology.org/data_1385", "term": "Hybrid sequence alignment" }, "format": [] } ], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_0349", "term": "Sequence database search (by property)" } ], "input": [], "output": [ { "data": { "uri": "http://edamontology.org/data_1026", "term": "Gene symbol" }, "format": [] }, { "data": { "uri": "http://edamontology.org/data_1027", "term": "Gene ID (NCBI)" }, "format": [] }, { "data": { "uri": "http://edamontology.org/data_2299", "term": "Gene name" }, "format": [] }, { "data": { "uri": "http://edamontology.org/data_3494", "term": "DNA sequence" }, "format": [] } ], "note": null, "cmd": null } ], "toolType": [ "Database portal" ], "topic": [ { "uri": "http://edamontology.org/topic_3297", "term": "Biotechnology" }, { "uri": "http://edamontology.org/topic_3301", "term": "Microbiology" }, { "uri": "http://edamontology.org/topic_0821", "term": "Enzymes" } ], "operatingSystem": [], "language": [], "license": null, "collectionID": [], "maturity": "Mature", "cost": "Free of charge", "accessibility": "Open access", "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [ { "doi": "10.1093/database/bav033", "pmid": null, "pmcid": null, "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "BioSurfDB: Knowledge and algorithms to support biosurfactants and biodegradation studies", "abstract": "Crude oil extraction, transportation and use provoke the contamination of countless ecosystems. Therefore, bioremediation through surfactants mobilization or biodegradation is an important subject, both economically and environmentally. Bioremediation research had a great boost with the recent advances in Metagenomics, as it enabled the sequencing of uncultured microorganisms providing new insights on surfactant-producing and/or oil-degrading bacteria. Many research studies are making available genomic data from unknown organisms obtained from metagenomics analysis of oil-contaminated environmental samples. These new datasets are presently demanding the development of new tools and data repositories tailored for the biological analysis in a context of bioremediation data analysis. This work presents BioSurfDB, www.biosurfdb.org, a curated relational information system integrating data from: (i) metagenomes; (ii) organisms; (iii) biodegradation relevant genes; proteins and their metabolic pathways; (iv) bioremediation experiments results, with specific pollutants treatment efficiencies by surfactant producing organisms; and (v) a biosurfactant-curated list, grouped by producing organism, surfactant name, class and reference. The main goal of this repository is to gather information on the characterization of biological compounds and mechanisms involved in biosurfactant production and/or biodegradation and make it available in a curated way and associated with a number of computational tools to support studies of genomic and metagenomic data.", "date": "2015-01-01T00:00:00Z", "citationCount": 30, "authors": [ { "name": "Oliveira J.S." }, { "name": "Araujo W." }, { "name": "Sales A.I.L." }, { "name": "De Brito Guerra A." }, { "name": "Da Silva Araujo S.C." }, { "name": "De Vasconcelos A.T.R." }, { "name": "Agnez-Lima L.F." }, { "name": "Freitas A.T." } ], "journal": "Database" } } ], "credit": [ { "name": "Jorge S. Oliveira", "email": "jorge.oliveira@tecnico.ulisboa.pt", "url": "https://web.tecnico.ulisboa.pt/jorge.oliveira/", "orcidid": "https://orcid.org/0000-0001-6425-2176", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null }, { "name": "Ana Teresa Freitas", "email": "ana.freitas@tecnico.ulisboa.pt", "url": null, "orcidid": "http://orcid.org/0000-0003-4638-2879", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null }, { "name": "Ana Tereza Ribeiro de Vasconcelos", "email": "atrv@lncc.br", "url": null, "orcidid": "http://orcid.org/0000-0002-4632-2086", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null }, { "name": "Lucymara Fassarella Agnez-Lima", "email": "lucymara.agnez@ufrn.br", "url": null, "orcidid": "http://orcid.org/0000-0003-0642-3162", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null }, { "name": "Gil Poiares-Oliveira", "email": "gpo@biodata.pt", "url": "https://web.tecnico.ulisboa.pt/gil.oliveira", "orcidid": "https://orcid.org/0000-0003-4638-2879", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Maintainer" ], "note": null } ], "owner": "ELIXIR-PT", "additionDate": "2025-04-29T17:07:56.642694Z", "lastUpdate": "2025-04-29T17:35:41.655075Z", "editPermission": { "type": "group", "authors": [ "gpo" ] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "DICOM File Integrity Checker", "description": "The tool performs a DICOM quality check in terms of correct number of files per sequence, corrupted files, precise directory hierarchy, separated dynamic series merging them, interest series filtering/selection by specific series description lists and diffusion sequence identification by b-values. It applies the desired changes to the dataset and generates a report containing information about the selected sequences, corrupted files, missing files and merged files.\n\nStatus : Containerized", "homepage": "https://harbor.eucaim.cancerimage.eu/harbor/projects/3/repositories/dicom_file_integrity_checker/artifacts-tab", "biotoolsID": "dicom_file_integrity_checker_by_gibi230", "biotoolsCURIE": "biotools:dicom_file_integrity_checker_by_gibi230", "version": [ "1.2.9", "2.0.0" ], "otherID": [], "relation": [], "function": [], "toolType": [ "Library" ], "topic": [ { "uri": "http://edamontology.org/topic_3316", "term": "Computer science" }, { "uri": "http://edamontology.org/topic_3077", "term": "Data acquisition" }, { "uri": "http://edamontology.org/topic_3071", "term": "Data management" } ], "operatingSystem": [ "Linux", "Windows" ], "language": [ "Python" ], "license": null, "collectionID": [ "EUCAIM" ], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://www.linkedin.com/company/grupo-de-investigaci%C3%B3n-biom%C3%A9dica-en-imagen/", "type": [ "Social media" ], "note": null } ], "download": [], "documentation": [ { "url": "https://drive.google.com/file/d/1s8-nVAvSuAGTHWwun4AQcgHtRWclsFg2/view?usp=sharing", "type": [ "General" ], "note": "Pedro-Miguel Martinez-Girones 1,*, Adrian Galiana-Bordera 1, Carina Soler-Pons 1, Ignacio Gomez-Rico-Junquero 1, Ignacio Blanquer-Espert 3, Leonor Cerda-Alberich 1 and Luis Marti-Bonmati 1,2\n1\tBiomedical Imaging Research Group (GIBI230), La Fe Health Research Institute (IIS La Fe), Avenida Fernando Abril Martorell, València, 46026, Spain.\n2\tLa Fe Medical Imaging Department, Avenida Fernando Abril Martorell, València, 46026, Spain.\n3\tComputing Science Department, Universitat Politècnica de València, Cami de Vera s/n, València, 46022, Spain." } ], "publication": [], "credit": [ { "name": "GIBI230 - HULAFE", "email": null, "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": null, "typeRole": [], "note": null } ], "owner": "pedromiguel_martinez_HULAFE", "additionDate": "2025-04-15T17:42:40.968987Z", "lastUpdate": "2025-04-29T14:29:57.293088Z", "editPermission": { "type": "group", "authors": [ "casopon" ] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "Data Ingestion Tool (UPV Reference Node)", "description": "User Interface Tool to ingest data to the UPV Reference Node through the QP-Insights API", "homepage": "https://harbor.eucaim.cancerimage.eu/harbor/projects/3/repositories/data_ingestion_tool_upv_reference_node/artifacts-tab", "biotoolsID": "data_ingestion_tool_upv_reference_node", "biotoolsCURIE": "biotools:data_ingestion_tool_upv_reference_node", "version": [ "1.0.5" ], "otherID": [], "relation": [], "function": [], "toolType": [ "Web application" ], "topic": [ { "uri": "http://edamontology.org/topic_3366", "term": "Data integration and warehousing" }, { "uri": "http://edamontology.org/topic_3372", "term": "Software engineering" }, { "uri": "http://edamontology.org/topic_3382", "term": "Imaging" } ], "operatingSystem": [ "Windows" ], "language": [ "Python" ], "license": null, "collectionID": [ "EUCAIM" ], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://www.linkedin.com/company/grupo-de-investigaci%C3%B3n-biom%C3%A9dica-en-imagen/", "type": [ "Social media" ], "note": null } ], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "casopon", "additionDate": "2025-04-17T13:07:06.039592Z", "lastUpdate": "2025-04-29T14:28:43.124748Z", "editPermission": { "type": "group", "authors": [ "pedromiguel_martinez_HULAFE", "casopon" ] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "GO enrichment analysis tool", "description": "A tool for GO term enrichment analysis.", "homepage": "http://geneontology.org/page/go-enrichment-analysis", "biotoolsID": "go_enrichment_tool", "biotoolsCURIE": "biotools:go_enrichment_tool", "version": [], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3501", "term": "Enrichment analysis" } ], "input": [], "output": [], "note": null, "cmd": null } ], "toolType": [ "Web application" ], "topic": [ { "uri": "http://edamontology.org/topic_0077", "term": "Nucleic acids" }, { "uri": "http://edamontology.org/topic_0078", "term": "Proteins" }, { "uri": "http://edamontology.org/topic_0089", "term": "Ontology and terminology" } ], "operatingSystem": [ "Linux", "Windows", "Mac" ], "language": [], "license": null, "collectionID": [ "GO Tools" ], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [ { "url": "http://geneontology.org/page/go-enrichment-analysis", "type": [ "General" ], "note": null } ], "publication": [ { "doi": "10.1038/75556", "pmid": "10802651", "pmcid": "PMC3037419", "type": [], "version": null, "note": null, "metadata": null }, { "doi": "10.1093/nar/gku1179", "pmid": "25428369", "pmcid": "PMC4383973", "type": [], "version": null, "note": null, "metadata": null } ], "credit": [ { "name": null, "email": null, "url": "http://geneontology.org/form/contact-go", "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null } ], "owner": "training_go_import", "additionDate": "2017-01-17T15:08:16Z", "lastUpdate": "2025-04-29T13:02:02.508664Z", "editPermission": { "type": "group", "authors": [ "Taufik" ] }, "validated": 1, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "Trace4MedicalImageCleaning", "description": "Trace4MedicalImageCleaning™ is a tool aimed at automatically detecting and removing text in medical images, with a specific focus on 2D ultrasound and mammography studies.", "homepage": "http://deeptracetech.com/", "biotoolsID": "trace4medicalimagecleaning", "biotoolsCURIE": "biotools:trace4medicalimagecleaning", "version": [ "1.0" ], "otherID": [], "relation": [], "function": [], "toolType": [ "Library" ], "topic": [], "operatingSystem": [ "Windows", "Linux" ], "language": [ "MATLAB", "Python" ], "license": "Proprietary", "collectionID": [ "EUCAIM" ], "maturity": "Emerging", "cost": "Commercial", "accessibility": "Restricted access", "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "christian.salvatore", "additionDate": "2024-11-18T14:47:41.753481Z", "lastUpdate": "2025-04-29T10:39:22.111602Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "MetExplore", "description": "Metabolic network curation, visualisation and omics data analysis. It is possible to curate and annotate metabolic networks in a collaborative environment. Several tools are available for metabolomics data mapping in networks and visualisation.", "homepage": "http://www.metexplore.fr/", "biotoolsID": "metexplore", "biotoolsCURIE": "biotools:metexplore", "version": [ "2.40" ], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_2497", "term": "Pathway or network analysis" }, { "uri": "http://edamontology.org/operation_3083", "term": "Pathway or network visualisation" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_2600", "term": "Pathway or network" }, "format": [ { "uri": "http://edamontology.org/format_2585", "term": "SBML" } ] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_2600", "term": "Pathway or network" }, "format": [ { "uri": "http://edamontology.org/format_3620", "term": "xlsx" }, { "uri": "http://edamontology.org/format_3822", "term": "GML" }, { "uri": "http://edamontology.org/format_2585", "term": "SBML" }, { "uri": "http://edamontology.org/format_3603", "term": "PNG" }, { "uri": "http://edamontology.org/format_3579", "term": "JPG" }, { "uri": "http://edamontology.org/format_3604", "term": "SVG" } ] } ], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_0277", "term": "Pathway or network comparison" }, { "uri": "http://edamontology.org/operation_3083", "term": "Pathway or network visualisation" } ], "input": [], "output": [], "note": null, "cmd": null } ], "toolType": [ "Web application", "Web service", "Workbench" ], "topic": [ { "uri": "http://edamontology.org/topic_0602", "term": "Molecular interactions, pathways and networks" } ], "operatingSystem": [ "Linux", "Windows", "Mac" ], "language": [], "license": null, "collectionID": [ "elixir-fr-sdp-2019", "EBI Training Tools" ], "maturity": "Mature", "cost": "Free of charge", "accessibility": "Open access", "elixirPlatform": [ "Tools" ], "elixirNode": [ "France" ], "elixirCommunity": [], "link": [], "download": [], "documentation": [ { "url": "https://metexplore.toulouse.inra.fr/metexplore-doc/index.php", "type": [ "User manual" ], "note": "User documentation on MetExplore main features." }, { "url": "https://metexplore.toulouse.inra.fr/metexploreViz/doc/documentation.php", "type": [ "User manual" ], "note": "MetExploreViz (metabolic network visualsiation) documentation." }, { "url": "https://metexplore.toulouse.inra.fr/metexplore-webservice-documentation/", "type": [ "API documentation" ], "note": "MetExplore webservice documentation" }, { "url": "https://metexplore.pages.mia.inra.fr/metexplore-training/", "type": [ "Training material" ], "note": "How to use MetExplore to map metabolomics data onto metabolic networks." } ], "publication": [ { "doi": "10.1093/nar/gky301", "pmid": "29718355", "pmcid": "PMC6030842", "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "MetExplore: Collaborative edition and exploration of metabolic networks", "abstract": "Metabolism of an organism is composed of hundreds to thousands of interconnected biochemical reactions responding to environmental or genetic constraints. This metabolic network provides a rich knowledge to contextualize omics data and to elaborate hypotheses on metabolic modulations. Nevertheless, performing this kind of integrative analysis is challenging for end users with not sufficiently advanced computer skills since it requires the use of various tools and web servers. MetExplore offers an all-in-one online solution composed of interactive tools for metabolic network curation, network exploration and omics data analysis. In particular, it is possible to curate and annotate metabolic networks in a collaborative environment. The network exploration is also facilitated in MetExplore by a system of interactive tables connected to a powerful network visualization module. Finally, the contextualization of metabolic elements in the network and the calculation of over-representation statistics make it possible to interpret any kind of omics data.", "date": "2018-07-02T00:00:00Z", "citationCount": 92, "authors": [ { "name": "Cottret L." }, { "name": "Frainay C." }, { "name": "Chazalviel M." }, { "name": "Cabanettes F." }, { "name": "Gloaguen Y." }, { "name": "Camenen E." }, { "name": "Merlet B." }, { "name": "Heux S." }, { "name": "Portais J.-C." }, { "name": "Poupin N." }, { "name": "Vinson F." }, { "name": "Jourdan F." } ], "journal": "Nucleic Acids Research" } }, { "doi": "10.1093/nar/gkq312", "pmid": "20444866", "pmcid": "PMC2896158", "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "MetExplore: A web server to link metabolomic experiments and genome-scale metabolic networks", "abstract": "High-throughput metabolomic experiments aim at identifying and ultimately quantifying all metabolites present in biological systems. The metabolites are interconnected through metabolic reactions, generally grouped into metabolic pathways. Classical metabolic maps provide a relational context to help interpret metabolomics experiments and a wide range of tools have been developed to help place metabolites within metabolic pathways. However, the representation of metabolites within separate disconnected pathways overlooks most of the connectivity of the metabolome. By definition, reference pathways cannot integrate novel pathways nor show relationships between metabolites that may be linked by common neighbours without being considered as joint members of a classical biochemical pathway. MetExplore is a web server that offers the possibility to link metabolites identified in untargeted metabolomics experiments within the context of genome-scale reconstructed metabolic networks. The analysis pipeline comprises mapping metabolomics data onto the specific metabolic network of an organism, then applying graph-based methods and advanced visualization tools to enhance data analysis. The MetExplore web server is freely accessible at http://metexplore.toulouse.inra.fr. © The Author(s) 2010. Published by Oxford University Press.", "date": "2010-05-05T00:00:00Z", "citationCount": 144, "authors": [ { "name": "Cottret L." }, { "name": "Wildridge D." }, { "name": "Vinson F." }, { "name": "Barrett M.P." }, { "name": "Charles H." }, { "name": "Sagot M.-F." }, { "name": "Jourdan F." } ], "journal": "Nucleic Acids Research" } }, { "doi": "10.1093/bioinformatics/btx588", "pmid": "28968733", "pmcid": "PMC5860210", "type": [ "Method" ], "version": null, "note": null, "metadata": { "title": "MetExploreViz: Web component for interactive metabolic network visualization", "abstract": "Summary MetExploreViz is an open source web component that can be easily embedded in any web site. It provides features dedicated to the visualization of metabolic networks and pathways and thus offers a flexible solution to analyse omics data in a biochemical context.", "date": "2018-01-15T00:00:00Z", "citationCount": 36, "authors": [ { "name": "Chazalviel M." }, { "name": "Frainay C." }, { "name": "Poupin N." }, { "name": "Vinson F." }, { "name": "Merlet B." }, { "name": "Gloaguen Y." }, { "name": "Cottret L." }, { "name": "Jourdan F." } ], "journal": "Bioinformatics" } } ], "credit": [ { "name": "Fabien JOURDAN", "email": "fabien.jourdan@inra.fr", "url": "https://sites.google.com/site/fabienjourdan/", "orcidid": "https://orcid.org/0000-0001-9401-2894", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null }, { "name": null, "email": "ludovic.cottret@inra.fr", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null }, { "name": null, "email": "metexplore@oulouse.inra.fr", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Support" ], "note": null }, { "name": "MetaboHub", "email": null, "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Consortium", "typeRole": [], "note": null } ], "owner": "fabienjourdan", "additionDate": "2018-07-09T23:06:59Z", "lastUpdate": "2025-04-28T07:17:11.601858Z", "editPermission": { "type": "group", "authors": [ "lcottret", "Jennifer" ] }, "validated": 1, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "EUCAIM DICOM Anonymizer", "description": "The EUCAIM DICOM Anonymizer anonymizes a set of DICOM files. It supports both anonymization on a case-by-case scenario, meaning one DICOM Study at a time (single-mode) or on multiple cases concurrently (batch mode). Additionally it hashes and links clinical data.", "homepage": "https://harbor.eucaim.cancerimage.eu/harbor/projects/3/repositories/eucaim-anonymizer/", "biotoolsID": "eucaim_dicom_anonymizer", "biotoolsCURIE": "biotools:eucaim_dicom_anonymizer", "version": [ "0.12.0" ], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3283", "term": "Anonymisation" } ], "input": [], "output": [], "note": null, "cmd": null } ], "toolType": [], "topic": [ { "uri": "http://edamontology.org/topic_3384", "term": "Medical imaging" } ], "operatingSystem": [ "Mac", "Windows", "Linux" ], "language": [ "C++" ], "license": null, "collectionID": [ "EUCAIM" ], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "vkalokyri", "additionDate": "2025-04-14T16:46:40.806977Z", "lastUpdate": "2025-04-24T13:06:17.802389Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "sylph", "description": "fast and precise species-level metagenomic profiling with ANIs", "homepage": "https://github.com/bluenote-1577/sylph", "biotoolsID": "sylph", "biotoolsCURIE": "biotools:sylph", "version": [ "v0.4.1" ], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3460", "term": "Taxonomic classification" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_3494", "term": "DNA sequence" }, "format": [ { "uri": "http://edamontology.org/format_1930", "term": "FASTQ" } ] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_3028", "term": "Taxonomy" }, "format": [ { "uri": "http://edamontology.org/format_3751", "term": "DSV" } ] } ], "note": null, "cmd": null } ], "toolType": [ "Command-line tool" ], "topic": [ { "uri": "http://edamontology.org/topic_3174", "term": "Metagenomics" } ], "operatingSystem": [ "Linux" ], "language": [], "license": null, "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "pauffret", "additionDate": "2023-12-06T15:45:20.587393Z", "lastUpdate": "2025-04-24T09:31:08.371089Z", "editPermission": { "type": "group", "authors": [ "vashokan" ] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "Longitools Exposome Toolbox", "description": "The LongITools toolbox is an open-source platform developed to support exposome research analysis. This cloud-based computational environment enables researchers to construct customized analytical platforms suited to their specific research requirements. The system provides a web-based interface that integrates various analytical resources, including statistical tools, computational pipelines, connections to external data repositories, and data visualization capabilities.", "homepage": "https://longitools.bsc.es/vre/", "biotoolsID": "longitools_exposome_toolbox", "biotoolsCURIE": "biotools:longitools_exposome_toolbox", "version": [ "2.0" ], "otherID": [], "relation": [], "function": [], "toolType": [ "Web application", "Command-line tool", "Web service" ], "topic": [ { "uri": "http://edamontology.org/topic_0091", "term": "Bioinformatics" }, { "uri": "http://edamontology.org/topic_3376", "term": "Medicines research and development" } ], "operatingSystem": [], "language": [ "R", "Python", "PHP" ], "license": null, "collectionID": [], "maturity": "Mature", "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://longitools.bsc.es/vre/", "type": [ "Other" ], "note": null } ], "download": [], "documentation": [ { "url": "https://github.com/inab/openVRE/tree/longitools", "type": [ "Quick start guide" ], "note": null } ], "publication": [], "credit": [ { "name": "Karim Lekadir", "email": "karim.lekadir@ub.edu", "url": null, "orcidid": "https://orcid.org/0000-0002-9456-1612", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": null, "typeRole": [ "Primary contact" ], "note": null } ], "owner": "noussair", "additionDate": "2025-04-23T10:31:12.521148Z", "lastUpdate": "2025-04-23T10:31:21.719823Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "Bracken", "description": "Statistical method that computes the abundance of species in DNA sequences from a metagenomics sample.", "homepage": "https://ccb.jhu.edu/software/bracken/", "biotoolsID": "bracken", "biotoolsCURIE": "biotools:bracken", "version": [], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_2238", "term": "Statistical calculation" } ], "input": [], "output": [], "note": null, "cmd": null } ], "toolType": [ "Command-line tool" ], "topic": [ { "uri": "http://edamontology.org/topic_3174", "term": "Metagenomics" }, { "uri": "http://edamontology.org/topic_3697", "term": "Microbial ecology" } ], "operatingSystem": [ "Linux" ], "language": [ "Perl", "Python" ], "license": "GPL-3.0", "collectionID": [ "Animal and Crop Genomics" ], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/jenniferlu717/Bracken", "type": [ "Repository" ], "note": null }, { "url": "https://github.com/jenniferlu717/Bracken/issues", "type": [ "Issue tracker" ], "note": null } ], "download": [], "documentation": [ { "url": "https://ccb.jhu.edu/software/bracken/index.shtml?t=manual", "type": [ "User manual" ], "note": null } ], "publication": [ { "doi": "10.7717/peerj-cs.104", "pmid": null, "pmcid": null, "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "Bracken: Estimating species abundance in metagenomics data", "abstract": "Metagenomic experiments attempt to characterize microbial communities using high-throughput DNA sequencing. Identification of the microorganisms in a sample provides information about the genetic profile, population structure, and role of microorganisms within an environment. Until recently, most metagenomics studies focused on high-level characterization at the level of phyla, or alternatively sequenced the 16S ribosomalRNAgene that is present in bacterial species. As the cost of sequencing has fallen, though, metagenomics experiments have increasingly used unbiased shotgun sequencing to capture all the organisms in a sample. This approach requires a method for estimating abundance directly from the raw read data. Here we describe a fast, accurate new method that computes the abundance at the species level using the reads collected in a metagenomics experiment. Bracken (Bayesian Reestimation of Abundance after Classification with KrakEN) uses the taxonomic assignments made by Kraken, a very fast read-level classifier, along with information about the genomes themselves to estimate abundance at the species level, the genus level, or above. We demonstrate that Bracken can produce accurate species- and genus-level abundance estimates even when a sample contains multiple near-identical species.", "date": "2017-01-01T00:00:00Z", "citationCount": 900, "authors": [ { "name": "Lu J." }, { "name": "Breitwieser F.P." }, { "name": "Thielen P." }, { "name": "Salzberg S.L." } ], "journal": "PeerJ Computer Science" } } ], "credit": [ { "name": null, "email": "jlu26@jhmi.edu", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null } ], "owner": "admin", "additionDate": "2017-08-20T15:17:20Z", "lastUpdate": "2025-04-23T07:43:18.805990Z", "editPermission": { "type": "group", "authors": [ "animalandcropgenomics", "ELIXIR-CZ", "bebatut", "vashokan" ] }, "validated": 1, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "Gemma", "description": "Gemma provides data, experimental design annotations, and differential expression analysis results for thousands of microarray and RNA-seq experiments. We re-analyze raw data from public sources (primarily NCBI GEO), annotate experimental conditions, conduct quality control and compute differential expression using standardized procedures. We have especially good coverage of experiments relevant to the nervous system.", "homepage": "https://gemma.msl.ubc.ca/", "biotoolsID": "gemma", "biotoolsCURIE": "biotools:gemma", "version": [ "1.31.13" ], "otherID": [], "relation": [ { "biotoolsID": "rsem", "type": "uses" }, { "biotoolsID": "multiqc", "type": "uses" }, { "biotoolsID": "cutadapt", "type": "uses" }, { "biotoolsID": "star", "type": "uses" }, { "biotoolsID": "ncbi_geo", "type": "uses" }, { "biotoolsID": "sradb", "type": "uses" }, { "biotoolsID": "ncbi_gene", "type": "uses" } ], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3223", "term": "Differential gene expression profiling" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_3112", "term": "Gene expression matrix" }, "format": [] }, { "data": { "uri": "http://edamontology.org/data_3110", "term": "Raw microarray data" }, "format": [] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_1636", "term": "Heat map" }, "format": [] }, { "data": { "uri": "http://edamontology.org/data_3914", "term": "Quality control report" }, "format": [] } ], "note": null, "cmd": null } ], "toolType": [ "Web application", "Web API" ], "topic": [ { "uri": "http://edamontology.org/topic_3170", "term": "RNA-Seq" }, { "uri": "http://edamontology.org/topic_0203", "term": "Gene expression" }, { "uri": "http://edamontology.org/topic_3053", "term": "Genetics" }, { "uri": "http://edamontology.org/topic_3518", "term": "Microarray experiment" }, { "uri": "http://edamontology.org/topic_0219", "term": "Data curation and archival" } ], "operatingSystem": [ "Linux", "Windows", "Mac" ], "language": [ "Java", "JavaScript" ], "license": "CC-BY-NC-4.0", "collectionID": [], "maturity": "Mature", "cost": "Free of charge (with restrictions)", "accessibility": "Open access (with restrictions)", "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/PavlidisLab/Gemma", "type": [ "Repository", "Issue tracker" ], "note": null } ], "download": [ { "url": "https://github.com/PavlidisLab/Gemma/releases", "type": "Downloads page", "note": null, "version": null } ], "documentation": [ { "url": "https://pavlidislab.github.io/Gemma/", "type": [ "General" ], "note": null }, { "url": "https://gemma.msl.ubc.ca/resources/restapidocs/", "type": [ "API documentation" ], "note": "Documentation for the Gemma REST API." } ], "publication": [ { "doi": "10.1093/bioinformatics/btp259", "pmid": "19376825", "pmcid": "PMC2687992", "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "Application and evaluation of automated semantic annotation of gene expression experiments", "abstract": "Motivation: Many microarray datasets are available online with formalized standards describing the probe sequences and expression values. Unfortunately, the description, conditions and parameters of the experiments are less commonly formalized and often occur as natural language text. This hinders searching, high-throughput analysis, organization and integration of the datasets. Results: We use the lexical resources and software tools from the Unified Medical Language System (UMLS) to extract concepts from text. We then link the UMLS concepts to classes in open biomedical ontologies. The result is accessible and clear semantic annotations of gene expression experiments. We applied the method to 595 expression experiments from Gemma, a resource for re-use and meta-analysis of gene expression profiling data. We evaluated and corrected all stages of the annotation process. The majority of missed annotations were due to a lack of cross-references. The most error-prone stage was the extraction of concepts from phrases. Final review of the annotations in context of the experiments revealed 89% precision. A naive system, lacking the phrase to concept corrections is 68% precise. We have integrated this annotation pipeline into Gemma. © 2009 The Author(s).", "date": "2009-06-09T00:00:00Z", "citationCount": 9, "authors": [ { "name": "French L." }, { "name": "Lane S." }, { "name": "Law T." }, { "name": "Xu L." }, { "name": "Pavlidis P." } ], "journal": "Bioinformatics" } }, { "doi": "10.1093/database/baab006", "pmid": "33599246", "pmcid": "PMC7904053", "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "Curation of over 10 000 transcriptomic studies to enable data reuse", "abstract": "Vast amounts of transcriptomic data reside in public repositories, but effective reuse remains challenging. Issues include unstructured dataset metadata, inconsistent data processing and quality control, and inconsistent probe-gene mappings across microarray technologies. Thus, extensive curation and data reprocessing are necessary prior to any reuse. The Gemma bioinformatics system was created to help address these issues. Gemma consists of a database of curated transcriptomic datasets, analytical software, a web interface and web services. Here we present an update on Gemma's holdings, data processing and analysis pipelines, our curation guidelines, and software features. As of June 2020, Gemma contains 10 811 manually curated datasets (primarily human, mouse and rat), over 395 000 samples and hundreds of curated transcriptomic platforms (both microarray and RNA sequencing). Dataset topics were represented with 10 215 distinct terms from 12 ontologies, for a total of 54 316 topic annotations (mean topics/dataset = 5.2). While Gemma has broad coverage of conditions and tissues, it captures a large majority of available brain-related datasets, accounting for 34% of its holdings. Users can access the curated data and differential expression analyses through the Gemma website, RESTful service and an R package. Database URL: https://gemma.msl.ubc.ca/home.html", "date": "2021-01-01T00:00:00Z", "citationCount": 21, "authors": [ { "name": "Lim N." }, { "name": "Tesar S." }, { "name": "Belmadani M." }, { "name": "Poirier-Morency G." }, { "name": "Mancarci B.O." }, { "name": "Sicherman J." }, { "name": "Jacobson M." }, { "name": "Leong J." }, { "name": "Tan P." }, { "name": "Pavlidis P." } ], "journal": "Database" } } ], "credit": [ { "name": "Pavlidis Lab Support", "email": "pavlab-support@msl.ubc.ca", "url": "https://pavlab.msl.ubc.ca/", "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Support" ], "note": null } ], "owner": "artrymix", "additionDate": "2017-04-22T17:35:18Z", "lastUpdate": "2025-04-22T22:09:03.811075Z", "editPermission": { "type": "group", "authors": [ "artrymix", "paulpavlidis" ] }, "validated": 1, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "MetaPhlAn", "description": "Computational tool for profiling the composition of microbial communities from metagenomic shotgun sequencing data.", "homepage": "http://segatalab.cibio.unitn.it/tools/metaphlan/index.html", "biotoolsID": "metaphlan", "biotoolsCURIE": "biotools:metaphlan", "version": [], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3460", "term": "Taxonomic classification" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_3494", "term": "DNA sequence" }, "format": [ { "uri": "http://edamontology.org/format_1930", "term": "FASTQ" }, { "uri": "http://edamontology.org/format_1929", "term": "FASTA" }, { "uri": "http://edamontology.org/format_2573", "term": "SAM" } ] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_3028", "term": "Taxonomy" }, "format": [ { "uri": "http://edamontology.org/format_3751", "term": "DSV" } ] } ], "note": null, "cmd": "metaphlan <fastq_input> --input_type fastq -o <output>" }, { "operation": [ { "uri": "http://edamontology.org/operation_3460", "term": "Taxonomic classification" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_3028", "term": "Taxonomy" }, "format": [ { "uri": "http://edamontology.org/format_3751", "term": "DSV" } ] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_3028", "term": "Taxonomy" }, "format": [ { "uri": "http://edamontology.org/format_3751", "term": "DSV" } ] } ], "note": "Convert SGB-based profile to GTDB taxonomy", "cmd": "sgb_to_gtdb_profile.py -i <metaphlan_output> -o <gtdb_metaphlan_output>" } ], "toolType": [ "Command-line tool" ], "topic": [ { "uri": "http://edamontology.org/topic_3174", "term": "Metagenomics" }, { "uri": "http://edamontology.org/topic_0194", "term": "Phylogenomics" } ], "operatingSystem": [ "Linux", "Windows", "Mac" ], "language": [ "Python" ], "license": "MIT", "collectionID": [ "Animal and Crop Genomics" ], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [ { "url": "https://github.com/biobakery/MetaPhlAn", "type": [ "General" ], "note": null } ], "publication": [ { "doi": "10.1038/nmeth.2066", "pmid": "22688413", "pmcid": "PMC3443552", "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "Metagenomic microbial community profiling using unique clade-specific marker genes", "abstract": "Metagenomic shotgun sequencing data can identify microbes populating a microbial community and their proportions, but existing taxonomic profiling methods are inefficient for increasingly large data sets. We present an approach that uses clade-specific marker genes to unambiguously assign reads to microbial clades more accurately and >50Ã-faster than current approaches. We validated our metagenomic phylogenetic analysis tool, MetaPhlAn, on terabases of short reads and provide the largest metagenomic profiling to date of the human gut. It can be accessed at http://huttenhower.sph.harvard.edu/ metaphlan/. © 2012 Nature America, Inc. All rights reserved.", "date": "2012-08-01T00:00:00Z", "citationCount": 1300, "authors": [ { "name": "Segata N." }, { "name": "Waldron L." }, { "name": "Ballarini A." }, { "name": "Narasimhan V." }, { "name": "Jousson O." }, { "name": "Huttenhower C." } ], "journal": "Nature Methods" } } ], "credit": [ { "name": null, "email": null, "url": "https://groups.google.com/forum/#!forum/metaphlan-users", "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null } ], "owner": "admin", "additionDate": "2017-08-20T15:57:59Z", "lastUpdate": "2025-04-22T12:44:24.859435Z", "editPermission": { "type": "group", "authors": [ "animalandcropgenomics", "ELIXIR-CZ", "bebatut", "vashokan" ] }, "validated": 1, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "samclip", "description": "Filter SAM file for soft and hard clipped alignments", "homepage": "https://github.com/tseemann/samclip", "biotoolsID": "samclip", "biotoolsCURIE": "biotools:samclip", "version": [ "0.4.0" ], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3192", "term": "Sequence trimming" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_1383", "term": "Nucleic acid sequence alignment" }, "format": [] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_1383", "term": "Nucleic acid sequence alignment" }, "format": [] } ], "note": null, "cmd": null } ], "toolType": [ "Command-line tool" ], "topic": [ { "uri": "http://edamontology.org/topic_0622", "term": "Genomics" }, { "uri": "http://edamontology.org/topic_0091", "term": "Bioinformatics" }, { "uri": "http://edamontology.org/topic_0102", "term": "Mapping" } ], "operatingSystem": [ "Linux", "Mac" ], "language": [ "Perl" ], "license": null, "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/tseemann/samclip", "type": [ "Repository" ], "note": null } ], "download": [ { "url": "https://anaconda.org/bioconda/samclip", "type": "Software package", "note": null, "version": "0.4.0" } ], "documentation": [ { "url": "https://github.com/tseemann/samclip", "type": [ "General" ], "note": null } ], "publication": [], "credit": [], "owner": "emmcauley", "additionDate": "2025-04-21T21:06:51.624399Z", "lastUpdate": "2025-04-21T21:06:51.626575Z", "editPermission": { "type": "group", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "NetPicoRNA", "description": "Neural network predictions of cleavage sites of picornaviral proteases.", "homepage": "http://cbs.dtu.dk/services/NetPicoRNA/", "biotoolsID": "netpicorna", "biotoolsCURIE": "biotools:netpicorna", "version": [ "1.0" ], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_0422", "term": "Protein cleavage site prediction" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_2044", "term": "Sequence" }, "format": [ { "uri": "http://edamontology.org/format_1929", "term": "FASTA" } ] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_1277", "term": "Protein features" }, "format": [ { "uri": "http://edamontology.org/format_2330", "term": "Textual format" } ] }, { "data": { "uri": "http://edamontology.org/data_2955", "term": "Sequence report" }, "format": [ { "uri": "http://edamontology.org/format_2333", "term": "Binary format" } ] } ], "note": "produces neural network predictions of cleavage sites of picornaviral proteases", "cmd": null } ], "toolType": [ "Web application" ], "topic": [ { "uri": "http://edamontology.org/topic_3510", "term": "Protein sites, features and motifs" }, { "uri": "http://edamontology.org/topic_0160", "term": "Sequence sites, features and motifs" } ], "operatingSystem": [ "Linux" ], "language": [], "license": "Other", "collectionID": [], "maturity": "Legacy", "cost": "Free of charge (with restrictions)", "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "http://cbs.dtu.dk/services", "type": [ "Software catalogue" ], "note": null } ], "download": [], "documentation": [ { "url": "http://www.cbs.dtu.dk/services/NetPicoRNA/instructions.php", "type": [ "General" ], "note": null } ], "publication": [ { "doi": "10.1002/pro.5560051107", "pmid": "8931139", "pmcid": "PMC2143287", "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "Cleavage site analysis in picornaviral polyproteins: Discovering cellular targets by neural networks", "abstract": "Picornaviral proteinases are responsible for maturation cleavages of the viral polyprotein, but also catalyze the degradation of cellular targets. Using graphical visualization techniques and neural network algorithms, we have investigated the sequence specificity of the two proteinases 2A(pro) and 3C(pro). The cleavage of VP0 (giving rise to VP2 and VP4), which is carried out by a so-far unknown proteinase, was also examined. In combination with a novel surface exposure prediction algorithm, our neural network approach successfully distinguishes known cleavage sites from noncleavage sites and yields a more consistent definition of features common to these sites. The method is able to predict experimentally determined cleavage sites in cellular proteins. We present a list of mammalian and other proteins that are predicted to be possible targets for the vital proteinases. Whether these proteins are indeed cleaved awaits experimental verification. Additionally, we report several errors detected in the protein databases.", "date": "1996-01-01T00:00:00Z", "citationCount": 204, "authors": [ { "name": "Blom N." }, { "name": "Hansen J." }, { "name": "Blaas D." }, { "name": "Brunak S." } ], "journal": "Protein Science" } } ], "credit": [ { "name": "CBS", "email": null, "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Institute", "typeRole": [ "Provider" ], "note": null }, { "name": "Nikolaj Sorgenfrei Blom", "email": "nikob@cbs.dtu.dk", "url": null, "orcidid": "https://orcid.org/0000-0001-7787-7853", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [], "note": null } ], "owner": "powehi", "additionDate": "2015-06-29T10:14:28Z", "lastUpdate": "2025-04-21T12:49:56.070719Z", "editPermission": { "type": "group", "authors": [ "powehi" ] }, "validated": 1, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "SLiM", "description": "Evolutionary simulation framework that combines a powerful engine for population genetic simulations with the capability of modeling arbitrarily complex evolutionary scenarios. Includes a graphical modeling environment.", "homepage": "https://messerlab.org/slim/", "biotoolsID": "SLiM_software", "biotoolsCURIE": "biotools:SLiM_software", "version": [ "5.0" ], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_0550", "term": "DNA substitution modelling" }, { "uri": "http://edamontology.org/operation_0230", "term": "Sequence generation" }, { "uri": "http://edamontology.org/operation_3946", "term": "Ecological modelling" } ], "input": [], "output": [], "note": "Run individual-based eco-evolutionary simulations with explicit genetics", "cmd": null } ], "toolType": [ "Command-line tool", "Desktop application" ], "topic": [ { "uri": "http://edamontology.org/topic_0610", "term": "Ecology" }, { "uri": "http://edamontology.org/topic_0602", "term": "Molecular interactions, pathways and networks" }, { "uri": "http://edamontology.org/topic_0199", "term": "Genetic variation" }, { "uri": "http://edamontology.org/topic_3299", "term": "Evolutionary biology" } ], "operatingSystem": [ "Linux", "Mac", "Windows" ], "language": [ "C++" ], "license": "GPL-3.0", "collectionID": [], "maturity": "Mature", "cost": "Free of charge", "accessibility": "Open access", "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://messerlab.org/slim/", "type": [ "Software catalogue" ], "note": "SLiM home page in the Messer Lab website" }, { "url": "https://github.com/MesserLab/SLiM", "type": [ "Repository" ], "note": "GitHub repository for SLiM" }, { "url": "https://groups.google.com/g/slim-discuss", "type": [ "Discussion forum" ], "note": "Discussion forum for SLiM questions" }, { "url": "https://groups.google.com/g/slim-announce", "type": [ "Mailing list" ], "note": "Announcements mailing list" } ], "download": [ { "url": "http://benhaller.com/slim/SLiM.zip", "type": "Source code", "note": "A source archive for the command-line `slim` tool only. Complete source code is on GitHub, but most platforms have an installer anyway; see the manual, chapter 2, for installation instructions.", "version": null }, { "url": "https://github.com/MesserLab/SLiM/releases/latest", "type": "Downloads page", "note": "The GitHub page for the current release version, to obtain full source code.", "version": null } ], "documentation": [ { "url": "http://benhaller.com/slim/SLiM_Manual.pdf", "type": [ "User manual" ], "note": "The manual for SLiM itself" }, { "url": "http://benhaller.com/slim/Eidos_Manual.pdf", "type": [ "User manual" ], "note": "The manual for Eidos, the scripting language used by SLiM" }, { "url": "http://benhaller.com/slim/SLiMEidosRefSheets.zip", "type": [ "Quick start guide" ], "note": "Quick reference sheets for SLiM and Eidos" } ], "publication": [ { "doi": "10.1093/molbev/msy228", "pmid": "30517680", "pmcid": "PMC6389312", "type": [ "Other" ], "version": null, "note": "B.C. Haller, P.W. Messer. (2019). SLiM 3: Forward genetic simulations beyond the Wright–Fisher Model. Molecular Biology and Evolution 36(3), 632–637.", "metadata": { "title": "SLiM 3: Forward Genetic Simulations Beyond the Wright-Fisher Model", "abstract": "With the desire to model population genetic processes under increasingly realistic scenarios, forward genetic simulations have become a critical part of the toolbox of modern evolutionary biology. The SLiM forward genetic simulation framework is one of the most powerful and widely used tools in this area. However, its foundation in the Wright-Fisher model has been found to pose an obstacle to implementing many types of models; it is difficult to adapt the Wright-Fisher model, with its many assumptions, to modeling ecologically realistic scenarios such as explicit space, overlapping generations, individual variation in reproduction, density-dependent population regulation, individual variation in dispersal or migration, local extinction and recolonization, mating between subpopulations, age structure, fitness-based survival and hard selection, emergent sex ratios, and so forth. In response to this need, we here introduce SLiM 3, which contains two key advancements aimed at abolishing these limitations. First, the new non-Wright-Fisher or \"nonWF\" model type provides a much more flexible foundation that allows the easy implementation of all of the above scenarios and many more. Second, SLiM 3 adds support for continuous space, including spatial interactions and spatial maps of environmental variables. We provide a conceptual overview of these new features, and present several example models to illustrate their use.", "date": "2019-03-01T00:00:00Z", "citationCount": 504, "authors": [ { "name": "Haller B.C." }, { "name": "Messer P.W." } ], "journal": "Molecular Biology and Evolution" } }, { "doi": "10.1093/molbev/msy237", "pmid": "30590560", "pmcid": "PMC6501880", "type": [ "Usage" ], "version": null, "note": "B.C. Haller, P.W. Messer. (2019). Evolutionary modeling in SLiM 3 for beginners. Molecular Biology and Evolution 36(5), 1101–1109.", "metadata": { "title": "Evolutionary Modeling in SLiM 3 for Beginners", "abstract": "The SLiM forward genetic simulation framework has proved to be a powerful and flexible tool for population genetic modeling. However, as a complex piece of software with many features that allow simulating a diverse assortment of evolutionary models, its initial learning curve can be difficult. Here we provide a step-by-step demonstration of how to build a simple evolutionary model in SLiM 3, to help new users get started. We will begin with a panmictic neutral model, and build up to a model of the evolution of a polygenic quantitative trait under selection for an environmental phenotypic optimum.", "date": "2019-05-01T00:00:00Z", "citationCount": 12, "authors": [ { "name": "Haller B.C." }, { "name": "Messer P.W." } ], "journal": "Molecular Biology and Evolution" } }, { "doi": "10.1111/1755-0998.12968", "pmid": "30565882", "pmcid": "PMC6393187", "type": [ "Method" ], "version": null, "note": "B.C. Haller, J. Galloway, J. Kelleher, P.W. Messer, P.L. Ralph. (2019). Tree-sequence recording in SLiM opens new horizons for forward-time simulation of whole genomes. Molecular Ecology Resources 19(2), 552–566.", "metadata": { "title": "Tree-sequence recording in SLiM opens new horizons for forward-time simulation of whole genomes", "abstract": "There is an increasing demand for evolutionary models to incorporate relatively realistic dynamics, ranging from selection at many genomic sites to complex demography, population structure, and ecological interactions. Such models can generally be implemented as individual-based forward simulations, but the large computational overhead of these models often makes simulation of whole chromosome sequences in large populations infeasible. This situation presents an important obstacle to the field that requires conceptual advances to overcome. The recently developed tree-sequence recording method (Kelleher, Thornton, Ashander, & Ralph, 2018), which stores the genealogical history of all genomes in the simulated population, could provide such an advance. This method has several benefits: (1) it allows neutral mutations to be omitted entirely from forward-time simulations and added later, thereby dramatically improving computational efficiency; (2) it allows neutral burn-in to be constructed extremely efficiently after the fact, using “recapitation”; (3) it allows direct examination and analysis of the genealogical trees along the genome; and (4) it provides a compact representation of a population's genealogy that can be analysed in Python using the msprime package. We have implemented the tree-sequence recording method in SLiM 3 (a free, open-source evolutionary simulation software package) and extended it to allow the recording of non-neutral mutations, greatly broadening the utility of this method. To demonstrate the versatility and performance of this approach, we showcase several practical applications that would have been beyond the reach of previously existing methods, opening up new horizons for the modelling and exploration of evolutionary processes.", "date": "2019-03-01T00:00:00Z", "citationCount": 109, "authors": [ { "name": "Haller B.C." }, { "name": "Galloway J." }, { "name": "Kelleher J." }, { "name": "Messer P.W." }, { "name": "Ralph P.L." } ], "journal": "Molecular Ecology Resources" } }, { "doi": "10.1086/723601", "pmid": "37130229", "pmcid": "PMC10793872", "type": [ "Primary" ], "version": null, "note": "B.C. Haller, P.W. Messer. (2023). SLiM 4: Multispecies eco-evolutionary modeling. The American Naturalist 201(5), E127–E139.", "metadata": { "title": "SLiM 4: Multispecies Eco-Evolutionary Modeling", "abstract": "The SLiM software framework for genetically explicit forward simulation has been widely used in population genetics. However, it has been largely restricted to modeling only a single species, which has limited its broader utility in evolutionary biology. Indeed, to our knowledge no general-purpose, flexible modeling framework exists that provides support for simulating multiple species while also providing other key features, such as explicit genetics and continuous space. The lack of such software has limited our ability to model higher biological levels such as communities, eco-systems, coevolutionary and eco-evolutionary processes, and bio-diversity, which is crucial for many purposes, from extending our basic understanding of evolutionary ecology to informing conservation and management decisions. We here announce the release of SLiM 4, which fills this important gap by adding support for multiple species, including ecological interactions between species such as predation, parasitism, and mutualism, and illustrate its new features with examples.", "date": "2023-05-01T00:00:00Z", "citationCount": 79, "authors": [ { "name": "Haller B.C." }, { "name": "Messer P.W." } ], "journal": "American Naturalist" } } ], "credit": [ { "name": "Philipp Messer", "email": "messer@cornell.edu", "url": "https://messerlab.org", "orcidid": "https://orcid.org/0000-0001-8453-9377", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null }, { "name": "Benjamin C. Haller", "email": "bhaller@benhaller.com", "url": "http://benhaller.com", "orcidid": "https://orcid.org/0000-0003-1874-8327", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null } ], "owner": "bchaller", "additionDate": "2019-05-27T16:59:15Z", "lastUpdate": "2025-04-18T17:40:38.228809Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "DICOM tags extractor", "description": "The tool scans the imaging DICOM files of a defined directory at the series level, and produces as output one single JSON file containing all the DICOM tags for each detected series.\nIf a list of selected DICOM tags is provided, the tool can also produce one single csv file containing the listed DICOM tags.\nTo use this tool, the user can download an executable file (.exe). Two execution modes are available : manual execution and command line execution.\nFor the tool to scan data successfully, it is important that : 1/ the extension “.dcm” is visible, as the tool only scans those files, and discard any other; 2/ each DICOM series has its own folder, as the tool gets a single .dcm file from each folder and extracts the tags.", "homepage": "https://www.bcplatforms.com/", "biotoolsID": "dicom_tags_extractor", "biotoolsCURIE": "biotools:dicom_tags_extractor", "version": [], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_0335", "term": "Data formatting" } ], "input": [], "output": [], "note": null, "cmd": null } ], "toolType": [ "Command-line tool" ], "topic": [ { "uri": "http://edamontology.org/topic_3365", "term": "Data architecture, analysis and design" }, { "uri": "http://edamontology.org/topic_3384", "term": "Medical imaging" } ], "operatingSystem": [], "language": [], "license": "Not licensed", "collectionID": [ "EUCAIM" ], "maturity": "Emerging", "cost": "Free of charge (with restrictions)", "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://www.bcplatforms.com/", "type": [ "Other" ], "note": null } ], "download": [], "documentation": [], "publication": [], "credit": [ { "name": "BC|Platforms", "email": null, "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": null, "typeRole": [], "note": null } ], "owner": "lsaint-aubert", "additionDate": "2025-04-18T15:04:18.411979Z", "lastUpdate": "2025-04-18T15:15:06.042639Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "eNRSA", "description": "eNRSA is an enhanced version of NRSA for analyzing nascent transcription profiles generated by PRO-seq, GRO-seq, (m)NET-seq, and Butt-seq data.", "homepage": "https://bioinfo.vanderbilt.edu/eNRSA/", "biotoolsID": "enrsa", "biotoolsCURIE": "biotools:enrsa", "version": [], "otherID": [], "relation": [], "function": [], "toolType": [], "topic": [], "operatingSystem": [], "language": [], "license": null, "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/chc-code/eNRSA", "type": [ "Software catalogue" ], "note": "link to github repo" } ], "download": [ { "url": "https://github.com/chc-code/eNRSA", "type": "Source code", "note": null, "version": null } ], "documentation": [ { "url": "https://bioinfo.vanderbilt.edu/eNRSA/", "type": [ "User manual" ], "note": null } ], "publication": [], "credit": [], "owner": "chcvandy", "additionDate": "2025-04-16T19:07:02.592454Z", "lastUpdate": "2025-04-16T19:07:12.773939Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "compareMS2", "description": "compareMS2 is a tool for comparing sets of (tandem) mass spectra for clustering samples, molecular phylogenetics, identification of biological species or tissues, and quality control. compareMS2 currently consumes Mascot Generic Format, or MGF, and produces output in a variety of common image and distance matrix formats.", "homepage": "https://github.com/524D/compareMS2", "biotoolsID": "comparems2", "biotoolsCURIE": "biotools:comparems2", "version": [ "1.0", "2.0" ], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_2424", "term": "Comparison" }, { "uri": "http://edamontology.org/operation_0567", "term": "Phylogenetic tree visualisation" } ], "input": [ { "data": { "uri": "http://edamontology.org/data_2536", "term": "Mass spectrometry data" }, "format": [ { "uri": "http://edamontology.org/format_3651", "term": "MGF" } ] } ], "output": [ { "data": { "uri": "http://edamontology.org/data_3272", "term": "Species tree" }, "format": [ { "uri": "http://edamontology.org/format_3603", "term": "PNG" }, { "uri": "http://edamontology.org/format_3604", "term": "SVG" } ] }, { "data": { "uri": "http://edamontology.org/data_2855", "term": "Distance matrix" }, "format": [ { "uri": "http://edamontology.org/format_1991", "term": "mega" }, { "uri": "http://edamontology.org/format_1912", "term": "Nexus format" }, { "uri": "http://edamontology.org/format_1910", "term": "newick" } ] } ], "note": null, "cmd": null } ], "toolType": [ "Command-line tool", "Desktop application" ], "topic": [ { "uri": "http://edamontology.org/topic_0084", "term": "Phylogeny" }, { "uri": "http://edamontology.org/topic_0121", "term": "Proteomics" }, { "uri": "http://edamontology.org/topic_3172", "term": "Metabolomics" }, { "uri": "http://edamontology.org/topic_3520", "term": "Proteomics experiment" } ], "operatingSystem": [ "Linux", "Windows", "Mac" ], "language": [ "C", "JavaScript" ], "license": "MIT", "collectionID": [ "ms-utils", "Proteomics" ], "maturity": "Mature", "cost": "Free of charge", "accessibility": null, "elixirPlatform": [], "elixirNode": [ "Netherlands" ], "elixirCommunity": [ "Proteomics" ], "link": [ { "url": "https://github.com/524D/compareMS2", "type": [ "Repository" ], "note": null }, { "url": "https://www.ms-utils.org/compareMS2.html", "type": [ "Software catalogue" ], "note": null }, { "url": "https://research-software-directory.org/software/comparems2", "type": [ "Software catalogue" ], "note": null } ], "download": [ { "url": "http://www.ms-utils.org/compareMS2.c", "type": "Source code", "note": null, "version": "1.0" }, { "url": "http://www.ms-utils.org/compareMS2.html", "type": "Binaries", "note": null, "version": "1.0" }, { "url": "http://www.ms-utils.org/compareMS2.c", "type": "Source code", "note": null, "version": "1.0" }, { "url": "https://github.com/524D/compareMS2/tree/main/src", "type": "Source code", "note": null, "version": "2.0" }, { "url": "https://github.com/524D/compareMS2/tree/main", "type": "Binaries", "note": null, "version": "2.0" } ], "documentation": [ { "url": "http://www.ms-utils.org/compareMS2.html", "type": [ "General", "Command-line options" ], "note": null }, { "url": "https://github.com/524D/compareMS2", "type": [ "General", "User manual", "Command-line options", "Installation instructions" ], "note": null } ], "publication": [ { "doi": "10.1002/rcm.6162", "pmid": "22368051", "pmcid": null, "type": [ "Primary" ], "version": "1.0", "note": null, "metadata": { "title": "Molecular phylogenetics by direct comparison of tandem mass spectra", "abstract": "Rationale: Molecular phylogenetics is the study of evolution and relatedness of organisms or genes. Mass spectrometry is used routinely for bacterial identification and has also been used for phylogenetic analysis, for instance from bone material. Unfortunately, only a small fraction of the acquired tandem mass spectra allow direct interpretation. Methods: We describe a new algorithm and software for molecular phylogenetics using pairwise comparisons of tandem mass spectra from enzymatically digested proteins. The spectra need not be annotated and all acquired data is used in the analysis. To demonstrate the method, we analyzed tryptic digests of sera from four great apes and two other primates. Results: The distribution of spectra dot products for thousands of tandem mass spectra collected from two samples provides a measure on the fraction of shared peptides between the two samples. When inverted, this becomes a distance metric. By pairwise comparison between species and averaging over four individuals per species, it was possible to reconstruct the unique correct phylogenetic tree for the great apes and other primates. Conclusions: The new method described here has several attractive features compared with existing methods, among them simplicity, the unbiased use of all acquired data rather than a small subset of spectra, and the potential use of heavily degraded proteins or proteins with a priori unknown modifications. © 2012 John Wiley & Sons, Ltd.", "date": "2012-04-15T00:00:00Z", "citationCount": 30, "authors": [ { "name": "Palmblad M." }, { "name": "Deelder A.M." } ], "journal": "Rapid Communications in Mass Spectrometry" } }, { "doi": "10.1021/acs.jproteome.2c00457", "pmid": "36173614", "pmcid": "PMC9903320", "type": [ "Primary" ], "version": "2.0", "note": null, "metadata": { "title": "compareMS2 2.0: An Improved Software for Comparing Tandem Mass Spectrometry Datasets", "abstract": "It has long been known that biological species can be identified from mass spectrometry data alone. Ten years ago, we described a method and software tool, compareMS2, for calculating a distance between sets of tandem mass spectra, as routinely collected in proteomics. This method has seen use in species identification and mixture characterization in food and feed products, as well as other applications. Here, we present the first major update of this software, including a new metric, a graphical user interface and additional functionality. The data have been deposited to ProteomeXchange with dataset identifier PXD034932.", "date": "2023-02-03T00:00:00Z", "citationCount": 7, "authors": [ { "name": "Marissen R." }, { "name": "Varunjikar M.S." }, { "name": "Laros J.F.J." }, { "name": "Rasinger J.D." }, { "name": "Neely B.A." }, { "name": "Palmblad M." } ], "journal": "Journal of Proteome Research" } }, { "doi": "10.1021/acs.jproteome.1c00528", "pmid": "34523928", "pmcid": "PMC8491155", "type": [ "Review" ], "version": "2.0", "note": null, "metadata": { "title": "Rewinding the Molecular Clock: Looking at Pioneering Molecular Phylogenetics Experiments in the Light of Proteomics", "abstract": "Science is full of overlooked and undervalued research waiting to be rediscovered. Proteomics is no exception. In this perspective, we follow the ripples from a 1960 study of Zuckerkandl, Jones, and Pauling comparing tryptic peptides across animal species. This pioneering work directly led to the molecular clock hypothesis and the ensuing explosion in molecular phylogenetics. In the decades following, proteins continued to provide essential clues on evolutionary history. While technology has continued to improve, contemporary proteomics has strayed from this larger biological context, rarely comparing species or asking how protein structure, function, and interactions have evolved. Here we recombine proteomics with molecular phylogenetics, highlighting the value of framing proteomic results in a larger biological context and how almost forgotten research, though technologically surpassed, can still generate new ideas and illuminate our work from a different perspective. Though it is infeasible to read all research published on a large topic, looking up older papers can be surprisingly rewarding when rediscovering a \"gem\"at the end of a long citation chain, aided by digital collections and perpetually helpful librarians. Proper literature study reduces unnecessary repetition and allows research to be more insightful and impactful by truly standing on the shoulders of giants. All data was uploaded to MassIVE (https://massive.ucsd.edu/) as dataset MSV000087993.", "date": "2021-10-01T00:00:00Z", "citationCount": 1, "authors": [ { "name": "Neely B.A." }, { "name": "Palmblad M." } ], "journal": "Journal of Proteome Research" } } ], "credit": [ { "name": "lumc.nl", "email": null, "url": "https://www.lumc.nl", "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Institute", "typeRole": [ "Support" ], "note": null }, { "name": "Magnus Palmblad", "email": "magnus.palmblad@gmail.com", "url": "https://github.com/magnuspalmblad", "orcidid": "http://orcid.org/0000-0002-5865-8994", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Developer", "Primary contact", "Documentor" ], "note": null }, { "name": "Rob Marissen", "email": null, "url": "https://github.com/524D", "orcidid": "https://orcid.org/0000-0002-1220-9173", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Developer" ], "note": null } ], "owner": "n.m.palmblad@lumc.nl", "additionDate": "2016-04-15T11:52:42Z", "lastUpdate": "2025-04-16T14:22:04.957317Z", "editPermission": { "type": "group", "authors": [ "proteomics.bio.tools" ] }, "validated": 1, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": "tool" }, { "name": "Radiomic features extraction", "description": "Implemented by GIBI230, this tool is a Docker-based software designed for extracting radiomic features from 3D medical images in NIfTI format using the PyRadiomics library (if DICOM images, the DICOM to NIFTI converter must be run before using this tool). It streamlines the radiomics calculation process by generating a structured CSV file containing all extracted variables from medical images.\nThe dockerized software enables users to configure parameters like filters, bin width, resampling spacing, and normalization settings can be specified. The output radiomic variables provide quantitative information for further analysis in medical imaging research and machine learning applications. \nSpecially important the parameter selection of the band width. For robust and reproducible results, a bin width of 5 is commonly recommended, but it should be adjusted based on image resolution, modality, and noise levels.", "homepage": "https://www.acim.lafe.san.gva.es/acim/?page_id=675&lang=es", "biotoolsID": "gibi230_radiomic_features_extraction", "biotoolsCURIE": "biotools:gibi230_radiomic_features_extraction", "version": [ "1.0.0" ], "otherID": [], "relation": [], "function": [], "toolType": [], "topic": [], "operatingSystem": [], "language": [ "Python" ], "license": null, "collectionID": [ "EUCAIM" ], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "pedromiguel_martinez_HULAFE", "additionDate": "2024-12-23T12:44:47.964606Z", "lastUpdate": "2025-04-16T12:17:50.036263Z", "editPermission": { "type": "group", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "openVRE", "description": "The Open Virtual Research Environment is a general purpose analysis platform that can be tailored for domain specific analyses.", "homepage": "https://github.com/inab/openVRE/wiki", "biotoolsID": "openvre", "biotoolsCURIE": "biotools:openvre", "version": [ "1.0" ], "otherID": [], "relation": [ { "biotoolsID": "mugvre", "type": "isNewVersionOf" } ], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3760", "term": "Service management" } ], "input": [], "output": [], "note": null, "cmd": null } ], "toolType": [ "Bioinformatics portal", "Workbench" ], "topic": [ { "uri": "http://edamontology.org/topic_0091", "term": "Bioinformatics" } ], "operatingSystem": [ "Linux" ], "language": [ "PHP", "Python", "JavaScript" ], "license": "Apache-2.0", "collectionID": [ "EUCAIM" ], "maturity": "Mature", "cost": "Free of charge", "accessibility": "Open access", "elixirPlatform": [ "Tools" ], "elixirNode": [ "Spain" ], "elixirCommunity": [], "link": [], "download": [ { "url": "https://github.com/inab/openVRE", "type": "Source code", "note": null, "version": "1.0" } ], "documentation": [ { "url": "http://vre.multiscalegenomics.eu/help/starting.php", "type": [ "Quick start guide" ], "note": "Getting Started Guide" } ], "publication": [], "credit": [ { "name": "Laia Codó", "email": "laia.codo@bsc.es", "url": "https://www.bsc.es/codo-laia", "orcidid": "https://orcid.org/0000-0002-6797-8746", "gridid": "grid.10097.3f", "rorid": "05sd8tv96", "fundrefid": "10.13039/501100006433", "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": "Senior Researcher at Barcelona Supercomputing Center. Lead of Trusted Research Environments and Cloud Computing at INB Lab." }, { "name": "Josep Lluís Gelpí", "email": "gelpi@ub.edu", "url": "https://webgrec.ub.edu/webpages/000011/ang/gelpi.ub.edu.html", "orcidid": "http://orcid.org/0000-0002-0566-7723", "gridid": "grid.5841.8", "rorid": "021018s57", "fundrefid": "10.13039/501100005774", "typeEntity": "Person", "typeRole": [ "Contributor" ], "note": "Professor at University of Barcelona and Team Leader at BSC's INB Laboratory" } ], "owner": "gelpi@ub.edu", "additionDate": "2025-04-16T08:53:57.270825Z", "lastUpdate": "2025-04-16T08:53:57.280528Z", "editPermission": { "type": "group", "authors": [ "gelpi@ub.edu" ] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": "tool" }, { "name": "Exposome Maps", "description": "The Exposome Maps contain geospatially resolved data on environmental exposures (Exposome Surfaces), categorized into the following Exposome dimensions:\nBuilt Environment28 exposures related to:\n•\tGreen space\n•\tBlue space\n•\tGrey space\nFood Environment4 exposures related to:\n•\tFood landscape / healthy food index\nPhysico-Chemical Environment99 exposures related to:\n•\tAir pollution\n•\tBiodiversity\n•\tWeather conditions\n•\tLight intensity at night\n•\tNoise\n•\tPesticides\n•\tElectromagnetic fields\nSocial Environment70 exposures related to:\n•\tNeighbourhood socio-economic position\n•\tNeighbourhood Demographic surfaces and population characteristics\n•\tSocial capital\n•\tSecurity\n•\tMental health\n•\tProximity to facilities\n•\tEnergy use\n•\tLabour market", "homepage": "https://exposome.dataplatform.nl/", "biotoolsID": "exposome_maps", "biotoolsCURIE": "biotools:exposome_maps", "version": [], "otherID": [], "relation": [], "function": [], "toolType": [], "topic": [ { "uri": "http://edamontology.org/topic_4012", "term": "FAIR data" }, { "uri": "http://edamontology.org/topic_3855", "term": "Environmental sciences" } ], "operatingSystem": [], "language": [], "license": "Other", "collectionID": [ "EXPANSE", "EHEN" ], "maturity": "Mature", "cost": "Free of charge (with restrictions)", "accessibility": "Restricted access", "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://expanseproject.eu/", "type": [ "Other" ], "note": "Project information page" } ], "download": [], "documentation": [ { "url": "https://surfdrive.surf.nl/files/index.php/s/uqUORDrd428H2F9", "type": [ "User manual" ], "note": "Description of Environmental variables available through Exposome Maps" }, { "url": "https://surfdrive.surf.nl/files/index.php/s/fI0Gmuu5O1MJAI9", "type": [ "Terms of use" ], "note": "Exposome-NL data platform Data Access and Publication Policy" } ], "publication": [ { "doi": "10.1126/science.aay3164", "pmid": null, "pmcid": null, "type": [], "version": null, "note": null, "metadata": { "title": "The exposome and health: Where chemistry meets biology", "abstract": "Despite extensive evidence showing that exposure to specific chemicals can lead to disease, current research approaches and regulatory policies fail to address the chemical complexity of our world. To safeguard current and future generations from the increasing number of chemicals polluting our environment, a systematic and agnostic approach is needed. The “exposome” concept strives to capture the diversity and range of exposures to synthetic chemicals, dietary constituents, psychosocial stressors, and physical factors, as well as their corresponding biological responses. Technological advances such as high-resolution mass spectrometry and network science have allowed us to take the first steps toward a comprehensive assessment of the exposome. Given the increased recognition of the dominant role that nongenetic factors play in disease, an effort to characterize the exposome at a scale comparable to that of the human genome is warranted.", "date": "2020-01-24T00:00:00Z", "citationCount": 597, "authors": [ { "name": "Vermeulen R." }, { "name": "Schymanski E.L." }, { "name": "Barabasi A.-L." }, { "name": "Miller G.W." } ], "journal": "Science" } }, { "doi": "10.1097/EE9.0000000000000162", "pmid": null, "pmcid": null, "type": [], "version": null, "note": null, "metadata": { "title": "Developing the building blocks to elucidate the impact of the urban exposome on cardiometabolic-pulmonary disease: The EU EXPANSE project", "abstract": "By 2030, more than 80% of Europe's population will live in an urban environment. The urban exposome, consisting of factors such as where we live and work, where and what we eat, our social network, and what chemical and physical hazards we are exposed to, provides important targets to improve population health. The EXPANSE (EXposome Powered tools for healthy living in urbAN SEttings) project will study the impact of the urban exposome on the major contributors to Europe's burden of disease: Cardio-Metabolic and Pulmonary Disease. EXPANSE will address one of the most pertinent questions for urban planners, policy makers, and European citizens: \"How to maximize one's health in a modern urban environment?\" EXPANSE will take the next step in exposome research by (1) bringing together exposome and health data of more than 55 million adult Europeans and OMICS information for more than 2 million Europeans; (2) perform personalized exposome assessment for 5,000 individuals in five urban regions; (3) applying ultra-high-resolution mass-spectrometry to screen for chemicals in 10,000 blood samples; (4) evaluating the evolution of the exposome and health through the life course; and (5) evaluating the impact of changes in the urban exposome on the burden of cardiometabolic and pulmonary disease. EXPANSE will translate its insights and innovations into research and dissemination tools that will be openly accessible via the EXPANSE toolbox. By applying innovative ethics-by-design throughout the project, the social and ethical acceptability of these tools will be safeguarded. EXPANSE is part of the European Human Exposome Network.", "date": "2021-08-01T00:00:00Z", "citationCount": 38, "authors": [ { "name": "Vlaanderen J." }, { "name": "De Hoogh K." }, { "name": "Hoek G." }, { "name": "Peters A." }, { "name": "Probst-Hensch N." }, { "name": "Scalbert A." }, { "name": "Melen E." }, { "name": "Tonne C." }, { "name": "De Wit G.A." }, { "name": "Chadeau-Hyam M." }, { "name": "Katsouyanni K." }, { "name": "Esko T." }, { "name": "Jongsma K.R." }, { "name": "Vermeulen R." } ], "journal": "Environmental Epidemiology" } } ], "credit": [ { "name": "Roel Vermeulen", "email": "R.C.H.Vermeulen@uu.nl", "url": null, "orcidid": "https://orcid.org/0000-0003-4082-8163", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": null, "typeRole": [ "Primary contact" ], "note": null }, { "name": "Zimbo Boudewijns", "email": "z.s.r.m.boudewijns@uu.nl", "url": null, "orcidid": "https://orcid.org/0000-0002-9383-9571", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": null, "typeRole": [ "Maintainer" ], "note": null }, { "name": "Lloyd Roga", "email": "l.q.roga@uu.nl", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": null, "typeRole": [ "Developer" ], "note": null } ], "owner": "Channel2291", "additionDate": "2025-03-17T14:01:59.601345Z", "lastUpdate": "2025-04-15T08:35:02.159681Z", "editPermission": { "type": "group", "authors": [ "hkucukali" ] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "hictkpy", "description": "Python bindings for hictk: read and write .cool and .hic files directly from Python", "homepage": "https://github.com/paulsengroup/hictkpy", "biotoolsID": "hictkpy", "biotoolsCURIE": "biotools:hictkpy", "version": [ "0.0.1", "0.0.2", "0.0.3", "0.0.4", "0.0.5", "1.0.0", "1.1.0", "1.2.0" ], "otherID": [], "relation": [ { "biotoolsID": "hictk", "type": "uses" } ], "function": [], "toolType": [ "Library" ], "topic": [ { "uri": "http://edamontology.org/topic_0091", "term": "Bioinformatics" }, { "uri": "http://edamontology.org/topic_0080", "term": "Sequence analysis" } ], "operatingSystem": [ "Linux", "Mac", "Windows" ], "language": [ "Python" ], "license": "MIT", "collectionID": [], "maturity": "Mature", "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/paulsengroup/hictkpy", "type": [ "Repository" ], "note": null }, { "url": "https://github.com/paulsengroup/hictkpy/issues", "type": [ "Issue tracker" ], "note": null }, { "url": "https://github.com/paulsengroup/hictkpy/discussions", "type": [ "Helpdesk" ], "note": null } ], "download": [ { "url": "https://github.com/paulsengroup/hictkpy/releases", "type": "Downloads page", "note": null, "version": null }, { "url": "https://pypi.org/project/hictkpy/", "type": "Binaries", "note": null, "version": null }, { "url": "https://anaconda.org/bioconda/hictkpy", "type": "Binaries", "note": null, "version": null } ], "documentation": [ { "url": "https://hictkpy.readthedocs.io/en/stable/", "type": [ "General" ], "note": null }, { "url": "https://hictkpy.readthedocs.io/en/stable/installation.html", "type": [ "Installation instructions" ], "note": null }, { "url": "https://hictkpy.readthedocs.io/en/stable/quickstart.html", "type": [ "Quick start guide" ], "note": null }, { "url": "https://hictkpy.readthedocs.io/en/stable/api/index.html", "type": [ "API documentation" ], "note": null } ], "publication": [ { "doi": "10.1093/bioinformatics/btae408", "pmid": null, "pmcid": null, "type": [], "version": null, "note": null, "metadata": { "title": "hictk: blazing fast toolkit to work with. hic and. cool files", "abstract": "Motivation: Hi-C is gaining prominence as a method for mapping genome organization. With declining sequencing costs and a growing demand for higher-resolution data, efficient tools for processing Hi-C datasets at different resolutions are crucial. Over the past decade, the. hic and Cooler file formats have become the de-facto standard to store interaction matrices produced by Hi-C experiments in binary format. Interoperability issues make it unnecessarily difficult to convert between the two formats and to develop applications that can process each format natively. Results: We developed hictk, a toolkit that can transparently operate on. hic and. cool files with excellent performance. The toolkit is written in C++ and consists of a C++ library with Python and R bindings as well as CLI tools to perform common operations directly from the shell, including converting between. hic and. mcool formats. We benchmark the performance of hictk and compare it with other popular tools and libraries. We conclude that hictk significantly outperforms existing tools while providing the flexibility of natively working with both file formats without code duplication.", "date": "2024-07-01T00:00:00Z", "citationCount": 0, "authors": [ { "name": "Rossini R." }, { "name": "Paulsen J." } ], "journal": "Bioinformatics" } } ], "credit": [], "owner": "robomics", "additionDate": "2024-04-18T08:31:46.459964Z", "lastUpdate": "2025-04-14T22:54:26.266145Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "hictk", "description": "Blazing fast toolkit to work with .hic and .cool files", "homepage": "https://github.com/paulsengroup/hictk", "biotoolsID": "hictk", "biotoolsCURIE": "biotools:hictk", "version": [ "0.0.1", "0.0.2", "0.0.3", "0.0.4", "0.0.5", "0.0.6", "0.0.7", "0.0.8", "0.0.9", "0.0.10", "0.0.11", "0.0.12", "1.0.0", "2.0.0", "2.0.1", "2.0.2", "2.1.0", "2.1.1" ], "otherID": [], "relation": [ { "biotoolsID": "hictkpy", "type": "usedBy" }, { "biotoolsID": "hictkr", "type": "usedBy" } ], "function": [], "toolType": [ "Command-line tool" ], "topic": [ { "uri": "http://edamontology.org/topic_0091", "term": "Bioinformatics" }, { "uri": "http://edamontology.org/topic_0080", "term": "Sequence analysis" } ], "operatingSystem": [ "Linux", "Mac", "Windows" ], "language": [], "license": "MIT", "collectionID": [], "maturity": "Mature", "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/paulsengroup/hictk", "type": [ "Repository" ], "note": null }, { "url": "https://github.com/paulsengroup/hictk/issues", "type": [ "Issue tracker" ], "note": null }, { "url": "https://github.com/paulsengroup/hictk/discussions", "type": [ "Helpdesk" ], "note": null } ], "download": [ { "url": "https://github.com/paulsengroup/hictk/releases", "type": "Downloads page", "note": null, "version": null }, { "url": "https://anaconda.org/bioconda/hictk", "type": "Binaries", "note": null, "version": null }, { "url": "https://github.com/paulsengroup/hictk/pkgs/container/hictk", "type": "Container file", "note": null, "version": null } ], "documentation": [ { "url": "https://hictk.readthedocs.io/en/stable/index.html", "type": [ "User manual" ], "note": null } ], "publication": [ { "doi": "10.1093/bioinformatics/btae408", "pmid": null, "pmcid": null, "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "hictk: blazing fast toolkit to work with. hic and. cool files", "abstract": "Motivation: Hi-C is gaining prominence as a method for mapping genome organization. With declining sequencing costs and a growing demand for higher-resolution data, efficient tools for processing Hi-C datasets at different resolutions are crucial. Over the past decade, the. hic and Cooler file formats have become the de-facto standard to store interaction matrices produced by Hi-C experiments in binary format. Interoperability issues make it unnecessarily difficult to convert between the two formats and to develop applications that can process each format natively. Results: We developed hictk, a toolkit that can transparently operate on. hic and. cool files with excellent performance. The toolkit is written in C++ and consists of a C++ library with Python and R bindings as well as CLI tools to perform common operations directly from the shell, including converting between. hic and. mcool formats. We benchmark the performance of hictk and compare it with other popular tools and libraries. We conclude that hictk significantly outperforms existing tools while providing the flexibility of natively working with both file formats without code duplication.", "date": "2024-07-01T00:00:00Z", "citationCount": 0, "authors": [ { "name": "Rossini R." }, { "name": "Paulsen J." } ], "journal": "Bioinformatics" } } ], "credit": [], "owner": "robomics", "additionDate": "2024-02-02T14:42:46.030561Z", "lastUpdate": "2025-04-14T22:54:16.319235Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "PR2", "description": "an 18S rRNA primer database for protists.\n\nAn interactive database of eukaryotic rRNA primers and primer sets for metabarcoding studies compiled from the literature.\n\nA database of eukaryotic rRNA primers and primer sets for metabarcoding studies compiled from the literature.", "homepage": "https://app.pr2-primers.org", "biotoolsID": "pr2", "biotoolsCURIE": "biotools:pr2", "version": [], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_0308", "term": "PCR primer design" }, { "uri": "http://edamontology.org/operation_3431", "term": "Deposition" }, { "uri": "http://edamontology.org/operation_3237", "term": "Primer removal" } ], "input": [], "output": [], "note": null, "cmd": null } ], "toolType": [ "Database portal", "Web application" ], "topic": [ { "uri": "http://edamontology.org/topic_0632", "term": "Probes and primers" }, { "uri": "http://edamontology.org/topic_3168", "term": "Sequencing" }, { "uri": "http://edamontology.org/topic_0659", "term": "Functional, regulatory and non-coding RNA" }, { "uri": "http://edamontology.org/topic_0621", "term": "Model organisms" }, { "uri": "http://edamontology.org/topic_3068", "term": "Literature and language" } ], "operatingSystem": [], "language": [ "R" ], "license": null, "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/pr2database/pr2-primers", "type": [ "Repository" ], "note": null } ], "download": [ { "url": "https://hub.docker.com/repository/docker/vaulot/pr2-primers", "type": "Container file", "note": null, "version": null } ], "documentation": [], "publication": [ { "doi": "10.1101/2021.01.04.425170", "pmid": null, "pmcid": null, "type": [], "version": null, "note": null, "metadata": null } ], "credit": [ { "name": "Daniel Vaulot", "email": "vaulot@gmail.com", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [], "note": null } ], "owner": "vaulot", "additionDate": "2021-03-19T08:44:58Z", "lastUpdate": "2025-04-14T13:56:12.948169Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": "tool" }, { "name": "The MINERVA Platform", "description": "The MINERVA (Molecular Interaction NEtwoRk VisuAlization) platform is a standalone webserver for visualization, exploration and management of molecular networks encoded in SBGN-compliant format, including files produced using CellDesigner or SBGN editors. Visualization of uploaded networks generated by the platform is accessible via a web browser to all viewers with the weblink to the resource.\n\nThe MINERVA Platform is a webservice using the Java Server Faces 2 technology. The server side, including data parsing, integration, annotation and verification, is implemented in Java. The platform uses the Postgres SQL database for data storage and the Hibernate framework as a middle layer between web server and database. The user web-interface is generated using React.js. The displayed content is visualized by OpenLayers API, dedicated JavaScript and CSS.", "homepage": "https://minerva.uni.lu", "biotoolsID": "MINERVA_Platform", "biotoolsCURIE": "biotools:MINERVA_Platform", "version": [ "13.1.3", "13.2.0", "14.0.13", "15.0.3", "16.4.0", "17.1.3", "18.1.1" ], "otherID": [], "relation": [ { "biotoolsID": "pathvisio", "type": "uses" }, { "biotoolsID": "sbgn", "type": "uses" }, { "biotoolsID": "libsbml", "type": "uses" } ], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_3926", "term": "Pathway visualisation" } ], "input": [], "output": [], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_0571", "term": "Expression data visualisation" } ], "input": [], "output": [], "note": null, "cmd": null } ], "toolType": [], "topic": [ { "uri": "http://edamontology.org/topic_0602", "term": "Molecular interactions, pathways and networks" }, { "uri": "http://edamontology.org/topic_3391", "term": "Omics" }, { "uri": "http://edamontology.org/topic_3342", "term": "Translational medicine" } ], "operatingSystem": [], "language": [], "license": "AGPL-3.0", "collectionID": [ "ELIXIR-LU", "LCSB" ], "maturity": "Mature", "cost": "Free of charge", "accessibility": "Open access", "elixirPlatform": [ "Tools" ], "elixirNode": [ "Luxembourg" ], "elixirCommunity": [], "link": [ { "url": "https://gitlab.lcsb.uni.lu/minerva/core/", "type": [ "Repository" ], "note": "GiLab repository for core functionalities (data and format handling, service stability, API access)" }, { "url": "https://gitlab.lcsb.uni.lu/minerva/core/-/issues", "type": [ "Issue tracker" ], "note": "Issue tracker for core functionalities (data and format handling, service stability, API access)" }, { "url": "https://gitlab.lcsb.uni.lu/minerva/frontend", "type": [ "Repository" ], "note": "GiLab repository for frontend functionalities" }, { "url": "https://gitlab.lcsb.uni.lu/minerva/frontend/-/issues", "type": [ "Issue tracker" ], "note": "Issue tracker for frontend functionalities" } ], "download": [ { "url": "https://minerva.pages.uni.lu/doc/install/", "type": "Other", "note": "Installation instructions, including debian package, virtual machine images and docker containers.", "version": "13.1.3 - 18.1.1" } ], "documentation": [ { "url": "https://minerva.uni.lu", "type": [ "Quick start guide", "Release notes", "User manual", "API documentation", "Citation instructions", "Terms of use" ], "note": null } ], "publication": [ { "doi": "10.1038/npjsba.2016.20", "pmid": "28725475", "pmcid": "PMC5516855", "type": [ "Primary" ], "version": "10.0", "note": null, "metadata": { "title": "MINERVA—A platform for visualization and curation of molecular interaction networks", "abstract": "Our growing knowledge about various molecular mechanisms is becoming increasingly more structured and accessible. Different repositories of molecular interactions and available literature enable construction of focused and high-quality molecular interaction networks. Novel tools for curation and exploration of such networks are needed, in order to foster the development of a systems biology environment. In particular, solutions for visualization, annotation and data cross-linking will facilitate usage of network-encoded knowledge in biomedical research. To this end we developed the MINERVA (Molecular Interaction NEtwoRks VisuAlization) platform, a standalone webservice supporting curation, annotation and visualization of molecular interaction networks in Systems Biology Graphical Notation (SBGN)-compliant format. MINERVA provides automated content annotation and verification for improved quality control. The end users can explore and interact with hosted networks, and provide direct feedback to content curators. MINERVA enables mapping drug targets or overlaying experimental data on the visualized networks. Extensive export functions enable downloading areas of the visualized networks as SBGN-compliant models for efficient reuse of hosted networks. The software is available under Affero GPL 3.0 as a Virtual Machine snapshot, Debian package and Docker instance at http://r3lab.uni.lu/web/minerva-website/. We believe that MINERVA is an important contribution to systems biology community, as its architecture enables set-up of locally or globally accessible SBGN-oriented repositories of molecular interaction networks. Its functionalities allow overlay of multiple information layers, facilitating exploration of content and interpretation of data. Moreover, annotation and verification workflows of MINERVA improve the efficiency of curation of networks, allowing life-science researchers to better engage in development and use of biomedical knowledge repositories.", "date": "2016-01-01T00:00:00Z", "citationCount": 60, "authors": [ { "name": "Gawron P." }, { "name": "Ostaszewski M." }, { "name": "Satagopam V." }, { "name": "Gebel S." }, { "name": "Mazein A." }, { "name": "Kuzma M." }, { "name": "Zorzan S." }, { "name": "McGee F." }, { "name": "Otjacques B." }, { "name": "Balling R." }, { "name": "Schneider R." } ], "journal": "npj Systems Biology and Applications" } }, { "doi": "10.1093/bioinformatics/btz286", "pmid": "31074494", "pmcid": "PMC6821317", "type": [ "Primary" ], "version": "12.2.3", "note": null, "metadata": { "title": "MINERVA API and plugins: Opening molecular network analysis and visualization to the community", "abstract": "Summary: The complexity of molecular networks makes them difficult to navigate and interpret, creating a need for specialized software. MINERVA is a web platform for visualization, exploration and management of molecular networks. Here, we introduce an extension to MINERVA architecture that greatly facilitates the access and use of the stored molecular network data. It allows to incorporate such data in analytical pipelines via a programmatic access interface, and to extend the platform's visual exploration and analytics functionality via plugin architecture. This is possible for any molecular network hosted by the MINERVA platform encoded in well-recognized systems biology formats. To showcase the possibilities of the plugin architecture, we have developed several plugins extending the MINERVA core functionalities. In the article, we demonstrate the plugins for interactive tree traversal of molecular networks, for enrichment analysis and for mapping and visualization of known disease variants or known adverse drug reactions to molecules in the network. Availability and implementation: Plugins developed and maintained by the MINERVA team are available under the AGPL v3 license at https://git-r3lab.uni.lu/minerva/plugins/. The MINERVA API and plugin documentation is available at https://minerva-web.lcsb.uni.lu.", "date": "2019-11-01T00:00:00Z", "citationCount": 24, "authors": [ { "name": "Hoksza D." }, { "name": "Gawron P." }, { "name": "Ostaszewski M." }, { "name": "Smula E." }, { "name": "Schneider R." } ], "journal": "Bioinformatics" } }, { "doi": "10.1093/bib/bbz067", "pmid": "31273380", "pmcid": "PMC7373180", "type": [ "Primary" ], "version": "13.1.1", "note": null, "metadata": { "title": "Closing the gap between formats for storing layout information in systems biology", "abstract": "The understanding of complex biological networks often relies on both a dedicated layout and a topology. Currently, there are three major competing layout-aware systems biology formats, but there are no software tools or software libraries supporting all of them. This complicates the management of molecular network layouts and hinders their reuse and extension. In this paper, we present a high-level overview of the layout formats in systems biology, focusing on their commonalities and differences, review their support in existing software tools, libraries and repositories and finally introduce a new conversion module within the MINERVA platform. The module is available via a REST API and offers, besides the ability to convert between layout-aware systems biology formats, the possibility to export layouts into several graphical formats. The module enables conversion of very large networks with thousands of elements, such as disease maps or metabolic reconstructions, rendering it widely applicable in systems biology.", "date": "2019-07-10T00:00:00Z", "citationCount": 15, "authors": [ { "name": "Hoksza D." }, { "name": "Gawron P." }, { "name": "Ostaszewski M." }, { "name": "Hasenauer J." }, { "name": "Schneider R." } ], "journal": "Briefings in Bioinformatics" } }, { "doi": "10.1089/big.2015.0057", "pmid": "27441714", "pmcid": "PMC4932659", "type": [ "Usage" ], "version": "10.0", "note": null, "metadata": { "title": "Integration and Visualization of Translational Medicine Data for Better Understanding of Human Diseases", "abstract": "Translational medicine is a domain turning results of basic life science research into new tools and methods in a clinical environment, for example, as new diagnostics or therapies. Nowadays, the process of translation is supported by large amounts of heterogeneous data ranging from medical data to a whole range of -omics data. It is not only a great opportunity but also a great challenge, as translational medicine big data is difficult to integrate and analyze, and requires the involvement of biomedical experts for the data processing. We show here that visualization and interoperable workflows, combining multiple complex steps, can address at least parts of the challenge. In this article, we present an integrated workflow for exploring, analysis, and interpretation of translational medicine data in the context of human health. Three Web services - tranSMART, a Galaxy Server, and a MINERVA platform - are combined into one big data pipeline. Native visualization capabilities enable the biomedical experts to get a comprehensive overview and control over separate steps of the workflow. The capabilities of tranSMART enable a flexible filtering of multidimensional integrated data sets to create subsets suitable for downstream processing. A Galaxy Server offers visually aided construction of analytical pipelines, with the use of existing or custom components. A MINERVA platform supports the exploration of health and disease-related mechanisms in a contextualized analytical visualization system. We demonstrate the utility of our workflow by illustrating its subsequent steps using an existing data set, for which we propose a filtering scheme, an analytical pipeline, and a corresponding visualization of analytical results. The workflow is available as a sandbox environment, where readers can work with the described setup themselves. Overall, our work shows how visualization and interfacing of big data processing services facilitate exploration, analysis, and interpretation of translational medicine data.", "date": "2016-06-01T00:00:00Z", "citationCount": 38, "authors": [ { "name": "Satagopam V." }, { "name": "Gu W." }, { "name": "Eifes S." }, { "name": "Gawron P." }, { "name": "Ostaszewski M." }, { "name": "Gebel S." }, { "name": "Barbosa-Silva A." }, { "name": "Balling R." }, { "name": "Schneider R." } ], "journal": "Big Data" } }, { "doi": "10.1016/j.envpol.2019.04.005", "pmid": "30991279", "pmcid": null, "type": [], "version": "13.1.1", "note": null, "metadata": { "title": "Genes associated with Parkinson's disease respond to increasing polychlorinated biphenyl levels in the blood of healthy females", "abstract": "Polychlorinated biphenyls (PCBs) are a class of widespread environmental pollutants, commonly found in human blood, that have been suggested to be linked to the occurrence of sporadic Parkinson's disease (PD). It has been reported that some non-coplanar PCBs accumulate in the brains of female PD patients. To improve our understanding of the association between PCB exposure and PD risk we have applied whole transcriptome gene expression analysis in blood cells from 594 PCB-exposed subjects (369 female, 225 male). Interestingly, we observe that in females, blood levels of non-coplanar PCBs appear to be associated with expression levels of PD-specific genes. However, no such association was detected in males. Among the 131 PD-specific genes affected, 39 have been shown to display similar changes in expression levels in the substantia nigra of deceased PD patients. Especially among the down-regulated genes, transcripts of genes involved in neurotransmitter vesicle-related functions were predominant. Capsule: Plasma PCB levels are associated with gene expression changes in females only, resulting in brain-related genes changing in blood cells of healthy individuals exposed to PCBs.", "date": "2019-07-01T00:00:00Z", "citationCount": 5, "authors": [ { "name": "Bohler S." }, { "name": "Krauskopf J." }, { "name": "Espin-Perez A." }, { "name": "Gebel S." }, { "name": "Palli D." }, { "name": "Rantakokko P." }, { "name": "Kiviranta H." }, { "name": "Kyrtopoulos S.A." }, { "name": "Balling R." }, { "name": "Kleinjans J." } ], "journal": "Environmental Pollution" } } ], "credit": [], "owner": "mjostaszewski", "additionDate": "2019-08-26T14:34:55Z", "lastUpdate": "2025-04-14T09:01:54.711218Z", "editPermission": { "type": "group", "authors": [ "sascha.herzinger" ] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "OpenCloning", "description": "An Open-Source web application to plan and document cloning and genome engineering", "homepage": "https://opencloning.org/", "biotoolsID": "opencloning", "biotoolsCURIE": "biotools:opencloning", "version": [], "otherID": [], "relation": [ { "biotoolsID": "pydna", "type": "uses" }, { "biotoolsID": "biopython", "type": "uses" }, { "biotoolsID": "primer3", "type": "uses" } ], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_0492", "term": "Multiple sequence alignment" } ], "input": [], "output": [], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_0491", "term": "Pairwise sequence alignment" } ], "input": [], "output": [], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_3095", "term": "Nucleic acid design" } ], "input": [], "output": [], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_0365", "term": "Restriction digest" } ], "input": [], "output": [], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_0230", "term": "Sequence generation" } ], "input": [], "output": [], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_3180", "term": "Sequence assembly validation" } ], "input": [], "output": [], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_3203", "term": "Chromatogram visualisation" } ], "input": [], "output": [], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_0573", "term": "Map drawing" } ], "input": [], "output": [], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_3925", "term": "Network visualisation" } ], "input": [], "output": [], "note": null, "cmd": null }, { "operation": [ { "uri": "http://edamontology.org/operation_0564", "term": "Sequence visualisation" } ], "input": [], "output": [], "note": null, "cmd": null } ], "toolType": [ "Web application", "Web API", "Library" ], "topic": [ { "uri": "http://edamontology.org/topic_3912", "term": "Genetic engineering" }, { "uri": "http://edamontology.org/topic_3047", "term": "Molecular biology" }, { "uri": "http://edamontology.org/topic_3895", "term": "Synthetic biology" } ], "operatingSystem": [], "language": [ "Python", "JavaScript" ], "license": "MIT", "collectionID": [], "maturity": "Emerging", "cost": "Free of charge", "accessibility": "Open access", "elixirPlatform": [], "elixirNode": [ "UK" ], "elixirCommunity": [], "link": [ { "url": "https://github.com/manulera/OpenCloning", "type": [ "Repository" ], "note": null }, { "url": "https://opencloning.org/", "type": [ "Service" ], "note": "Hosted web app" }, { "url": "https://github.com/manulera/OpenCloning_backend", "type": [ "Repository" ], "note": "Backend code" }, { "url": "https://github.com/manulera/OpenCloning_frontend", "type": [ "Repository" ], "note": null } ], "download": [], "documentation": [ { "url": "https://github.com/manulera/OpenCloning", "type": [ "General" ], "note": null } ], "publication": [], "credit": [ { "name": "Manuel Lera-Ramirez", "email": "manulera14@gmail.com", "url": "https://github.com/manulera", "orcidid": "https://orcid.org/0000-0002-8666-9746", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact" ], "note": null } ], "owner": "manulera", "additionDate": "2025-04-11T20:52:47.895200Z", "lastUpdate": "2025-04-11T20:53:03.390161Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": "tool" }, { "name": "metapr2", "description": "The metaPR2 database contains processed 18S rRNA metabarcodes that are annotated with the PR2 reference sequence database. Version 2.0 of the database contains 41 datasets corresponding to more than 6,000 samples and 90,000 ASVs. The database is accessible through both a web-based interface (https://app.metapr2.org) and an R package.", "homepage": "https://app.metapr2.org/", "biotoolsID": "metapr2", "biotoolsCURIE": "biotools:metapr2", "version": [], "otherID": [], "relation": [], "function": [], "toolType": [], "topic": [], "operatingSystem": [], "language": [], "license": null, "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "vaulot", "additionDate": "2025-04-11T14:04:51.838757Z", "lastUpdate": "2025-04-11T14:04:51.841101Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "Protists Ribosomal Reference Database", "description": "The PR2 reference sequence database was initiated in 2010 in the frame of the BioMarks project from work that had developed in the previous ten years in the Plankton Group of the Station Biologique of Roscoff. It aims to provide a reference database of carefully annotated 18S rRNA sequences using nine unique taxonomic fields (from domain to species). At present, it contains over 240,000 sequences. Although it focuses on protists, it also contains sequences from metazoa, fungi and plants as well a limited set of 16S sequences from plastids and bacteria. Several metadata fields are available for many sequences, including geo-localisation, whether it originates from a culture or a natural sample, host type etc… The annotation of PR2 is performed by experts from each taxonomic groups.", "homepage": "https://app.pr2-database.org/", "biotoolsID": "pr2-reference", "biotoolsCURIE": "biotools:pr2-reference", "version": [ "5.1.0" ], "otherID": [], "relation": [], "function": [], "toolType": [ "Database portal", "Web application" ], "topic": [ { "uri": "http://edamontology.org/topic_4038", "term": "Metabarcoding" } ], "operatingSystem": [], "language": [ "R" ], "license": null, "collectionID": [], "maturity": "Mature", "cost": "Free of charge", "accessibility": "Open access", "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [ { "url": "https://github.com/pr2database/pr2database/releases", "type": [ "Repository" ], "note": null }, { "url": "https://github.com/pr2database/pr2database/issues", "type": [ "Issue tracker" ], "note": null }, { "url": "https://pr2-database.org/", "type": [ "Other" ], "note": null } ], "download": [ { "url": "https://github.com/pr2database/pr2database/releases", "type": "Downloads page", "note": null, "version": "5.1.0" } ], "documentation": [ { "url": "https://pr2database.github.io/pr2database/articles/pr2database.html", "type": [ "User manual" ], "note": null } ], "publication": [ { "doi": "10.1093/nar/gks1160", "pmid": null, "pmcid": null, "type": [ "Primary" ], "version": null, "note": null, "metadata": { "title": "The Protist Ribosomal Reference database (PR2): A catalog of unicellular eukaryote Small Sub-Unit rRNA sequences with curated taxonomy", "abstract": "The interrogation of genetic markers in environmental meta-barcoding studies is currently seriously hindered by the lack of taxonomically curated reference data sets for the targeted genes. The Protist Ribosomal Reference database (PR2, http://ssu-rrna.org/) provides a unique access to eukaryotic small sub-unit (SSU) ribosomal RNA and DNA sequences, with curated taxonomy. The database mainly consists of nuclear-encoded protistan sequences. However, metazoans, land plants, macrosporic fungi and eukaryotic organelles (mitochondrion, plastid and others) are also included because they are useful for the analysis of high-troughput sequencing data sets. Introns and putative chimeric sequences have been also carefully checked. Taxonomic assignation of sequences consists of eight unique taxonomic fields. In total, 136866 sequences are nuclear encoded, 45708 (36 501 mitochondrial and 9657 chloroplastic) are from organelles, the remaining being putative chimeric sequences. The website allows the users to download sequences from the entire and partial databases (including representative sequences after clustering at a given level of similarity). Different web tools also allow searches by sequence similarity. The presence of both rRNA and rDNA sequences, taking into account introns (crucial for eukaryotic sequences), a normalized eight terms ranked-taxonomy and updates of new GenBank releases were made possible by a long-term collaboration between experts in taxonomy and computer scientists. © The Author(s) 2012.", "date": "2013-01-01T00:00:00Z", "citationCount": 1456, "authors": [ { "name": "Guillou L." }, { "name": "Bachar D." }, { "name": "Audic S." }, { "name": "Bass D." }, { "name": "Berney C." }, { "name": "Bittner L." }, { "name": "Boutte C." }, { "name": "Burgaud G." }, { "name": "De Vargas C." }, { "name": "Decelle J." }, { "name": "Del Campo J." }, { "name": "Dolan J.R." }, { "name": "Dunthorn M." }, { "name": "Edvardsen B." }, { "name": "Holzmann M." }, { "name": "Kooistra W.H.C.F." }, { "name": "Lara E." }, { "name": "Le Bescot N." }, { "name": "Logares R." }, { "name": "Mahe F." }, { "name": "Massana R." }, { "name": "Montresor M." }, { "name": "Morard R." }, { "name": "Not F." }, { "name": "Pawlowski J." }, { "name": "Probert I." }, { "name": "Sauvadet A.-L." }, { "name": "Siano R." }, { "name": "Stoeck T." }, { "name": "Vaulot D." }, { "name": "Zimmermann P." }, { "name": "Christen R." } ], "journal": "Nucleic Acids Research" } } ], "credit": [], "owner": "vaulot", "additionDate": "2025-04-11T13:56:02.037873Z", "lastUpdate": "2025-04-11T14:01:09.249274Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "RDMkit", "description": "RDMkit is the Research Data Management toolkit for Life Sciences, providing best practices and guidelines to for FAIR (Findable, Accessible, Interoperable and Reusable) data management.", "homepage": "https://rdmkit.elixir-europe.org", "biotoolsID": "rdmkit", "biotoolsCURIE": "biotools:rdmkit", "version": [], "otherID": [], "relation": [], "function": [], "toolType": [ "Web application" ], "topic": [], "operatingSystem": [ "Mac", "Linux", "Windows" ], "language": [ "Python" ], "license": "MIT", "collectionID": [], "maturity": null, "cost": "Free of charge", "accessibility": "Open access", "elixirPlatform": [ "Data", "Interoperability", "Training" ], "elixirNode": [ "UK", "Norway", "Belgium", "Germany", "Finland", "Spain" ], "elixirCommunity": [], "link": [ { "url": "https://github.com/elixir-europe/rdmkit", "type": [ "Repository" ], "note": null } ], "download": [ { "url": "https://zenodo.org/record/5110061", "type": "Downloads page", "note": null, "version": null } ], "documentation": [], "publication": [], "credit": [], "owner": "munazah", "additionDate": "2022-11-03T14:53:22.145643Z", "lastUpdate": "2025-04-11T13:03:16.201584Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": "tool" }, { "name": "avida", "description": "Avida is a software platform that mirrors key aspects of biological evolution, making it a useful twin for evolutionary studies.", "homepage": "https://github.com/devosoft/avida", "biotoolsID": "avida", "biotoolsCURIE": "biotools:avida", "version": [], "otherID": [], "relation": [], "function": [], "toolType": [], "topic": [], "operatingSystem": [], "language": [], "license": null, "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "Miguel", "additionDate": "2025-04-11T12:25:53.238464Z", "lastUpdate": "2025-04-11T12:25:53.241076Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "PLAZA 4.0", "description": "Integrative resource for functional, evolutionary and comparative plant genomics.\n\nPLAZA is an access point for plant comparative genomics, centralizing genomic data produced by different genome sequencing initiatives.\n\nThis intermediate update of the PLAZA platform, with a focus on the Monocots, became necessary due to substantial annotation updates to species present in the 4.0 PLAZA instances.", "homepage": "https://bioinformatics.psb.ugent.be/plaza", "biotoolsID": "plaza_4.0", "biotoolsCURIE": "biotools:plaza_4.0", "version": [], "otherID": [], "relation": [], "function": [ { "operation": [ { "uri": "http://edamontology.org/operation_0553", "term": "Gene tree construction" }, { "uri": "http://edamontology.org/operation_0558", "term": "Phylogenetic tree annotation" }, { "uri": "http://edamontology.org/operation_0567", "term": "Phylogenetic tree visualisation" } ], "input": [], "output": [], "note": null, "cmd": null } ], "toolType": [], "topic": [ { "uri": "http://edamontology.org/topic_0780", "term": "Plant biology" }, { "uri": "http://edamontology.org/topic_3293", "term": "Phylogenetics" }, { "uri": "http://edamontology.org/topic_0085", "term": "Functional genomics" }, { "uri": "http://edamontology.org/topic_0621", "term": "Model organisms" }, { "uri": "http://edamontology.org/topic_3697", "term": "Microbial ecology" } ], "operatingSystem": [ "Mac", "Linux", "Windows" ], "language": [], "license": null, "collectionID": [ "BIG N2N", "VIB", "UGent" ], "maturity": null, "cost": "Free of charge", "accessibility": "Open access", "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [ { "url": "https://bioinformatics.psb.ugent.be/plaza/documentation", "type": [ "User manual" ], "note": null } ], "publication": [ { "doi": "10.1093/NAR/GKX1002", "pmid": "29069403", "pmcid": "PMC5753339", "type": [], "version": null, "note": null, "metadata": { "title": "PLAZA 4.0: An integrative resource for functional, evolutionary and comparative plant genomics", "abstract": "PLAZA (https://bioinformatics.psb.ugent.be/plaza) is a plant-oriented online resource for comparative, evolutionary and functional genomics. The PLAZA platform consists of multiple independent instances focusing on different plant clades, while also providing access to a consistent set of reference species. Each PLAZA instance contains structural and functional gene annotations, gene family data and phylogenetic trees and detailed gene colinearity information. A user-friendly web interface makes the necessary tools and visualizations accessible, specific for each data type. Here we present PLAZA 4.0, the latest iteration of the PLAZA framework. This version consists of two new instances (Dicots 4.0 and Monocots 4.0) providing a large increase in newly available species, and offers access to updated and newly implemented tools and visualizations, helping users with the ever-increasing demands for complex and in-depth analyzes. The total number of species across both instances nearly doubles from 37 species in PLAZA 3.0 to 71 species in PLAZA 4.0, with a much broader coverage of crop species (e.g. wheat, palm oil) and species of evolutionary interest (e.g. spruce, Marchantia). The new PLAZA instances can also be accessed by a programming interface through a RESTful web service, thus allowing bioinformaticians to optimally leverage the power of the PLAZA platform.", "date": "2018-01-01T00:00:00Z", "citationCount": 338, "authors": [ { "name": "Van Bel M." }, { "name": "Diels T." }, { "name": "Vancaester E." }, { "name": "Kreft L." }, { "name": "Botzki A." }, { "name": "Van De Peer Y." }, { "name": "Coppens F." }, { "name": "Vandepoele K." } ], "journal": "Nucleic Acids Research" } } ], "credit": [ { "name": "Klaas Vandepoele", "email": "klaas.vandepoele@ugent.vib.be", "url": null, "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [], "note": null } ], "owner": "bits@vib.be", "additionDate": "2020-09-03T19:08:44Z", "lastUpdate": "2025-04-11T09:29:36.505334Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": "tool" }, { "name": "CellBinDB", "description": "We have released a large-scale, multimodal annotated dataset for cell segmentation, CellBinDB. Based on CellBinDB, we designed a benchmarking pipeline to benchmark eight of the most advanced and widely used cell segmentation techniques/methods, and further analyzed the impact of four cell morphology indicators and image gradients on the segmentation results.", "homepage": "https://github.com/STOmics/cs-benchmark", "biotoolsID": "cellbindb", "biotoolsCURIE": "biotools:cellbindb", "version": [], "otherID": [], "relation": [], "function": [], "toolType": [], "topic": [], "operatingSystem": [], "language": [], "license": null, "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "shican", "additionDate": "2025-04-10T03:18:36.031624Z", "lastUpdate": "2025-04-10T03:18:59.657512Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null }, { "name": "Cloud-based Workflow Manager (CloWM)", "description": "Data analysis in the life sciences often suffers from reproducibility, standardization and accessibility issues and these problems become even more severe with the escalating volume and complexity of data. While best-practice data analysis workflows try to tackle these challenges, many existing workflows still grapple with scalability issues, limited portability due to tight coupling with the execution environment and accessibility constraints arising from the absence of user-friendly interfaces. To overcome these issues, we created CloWM, a comprehensive cloud-based workflow management platform that allows the generic transformation of command-line driven workflows into user-friendly web-based services. CloWM offers the seamless integration of (1) scientific workflows written in the Nextflow DSL, (2) robust data storage, (3) a highly scalable compute layer for data-intensive analysis tasks and (4) a user-friendly interface.", "homepage": "https://clowm.bi.denbi.de", "biotoolsID": "clowm", "biotoolsCURIE": "biotools:clowm", "version": [], "otherID": [], "relation": [ { "biotoolsID": "sans", "type": "includes" } ], "function": [], "toolType": [ "Web API", "Web service", "Bioinformatics portal" ], "topic": [ { "uri": "http://edamontology.org/topic_0091", "term": "Bioinformatics" } ], "operatingSystem": [], "language": [ "Python", "JavaScript" ], "license": "Apache-2.0", "collectionID": [], "maturity": "Mature", "cost": "Free of charge", "accessibility": "Open access (with restrictions)", "elixirPlatform": [], "elixirNode": [ "Germany" ], "elixirCommunity": [], "link": [ { "url": "https://gitlab.ub.uni-bielefeld.de/cmg/clowm", "type": [ "Repository" ], "note": null } ], "download": [ { "url": "https://clowm.bi.denbi.de/api/v1/openapi.json", "type": "API specification", "note": null, "version": null }, { "url": "https://gitlab.ub.uni-bielefeld.de/cmg/clowm", "type": "Source code", "note": null, "version": null } ], "documentation": [ { "url": "https://clowm.bi.denbi.de/api/v1/docs", "type": [ "API documentation" ], "note": null }, { "url": "https://clowm.bi.denbi.de/terms", "type": [ "Terms of use" ], "note": null } ], "publication": [ { "doi": "10.5281/zenodo.14039069", "pmid": null, "pmcid": null, "type": [ "Other" ], "version": null, "note": null, "metadata": null } ], "credit": [ { "name": "Daniel Göbel", "email": "dgoebel@techfak.uni-bielefeld.de", "url": "https://ekvv.uni-bielefeld.de/pers_publ/publ/PersonDetail.jsp?personId=223066601", "orcidid": "https://orcid.org/0009-0009-9985-3823", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Maintainer", "Developer", "Primary contact" ], "note": null }, { "name": "Michael Beckstette", "email": "mbeckste@cebitec.uni-bielefeld.de", "url": null, "orcidid": "https://orcid.org/0000-0002-3707-1692", "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Person", "typeRole": [ "Primary contact", "Documentor" ], "note": null }, { "name": "Bielefeld University", "email": null, "url": "https://www.uni-bielefeld.de", "orcidid": null, "gridid": null, "rorid": "02hpadn98", "fundrefid": null, "typeEntity": "Institute", "typeRole": [ "Provider" ], "note": null }, { "name": "Genome Informatics", "email": null, "url": "https://gi.cebitec.uni-bielefeld.de", "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Institute", "typeRole": [ "Provider" ], "note": null }, { "name": "NFDI4Microbiota", "email": null, "url": "https://nfdi4microbiota.de", "orcidid": null, "gridid": null, "rorid": null, "fundrefid": null, "typeEntity": "Consortium", "typeRole": [], "note": null } ], "owner": "dgoebel", "additionDate": "2025-04-09T13:19:17.715967Z", "lastUpdate": "2025-04-09T14:21:50.981521Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": "tool" }, { "name": "Hi-cGAN", "description": "A software to predict Hi-C matrices based on ChIP-seq histone data using a cGAN approach.", "homepage": "https://github.com/joachimwolff/Hi-cGAN", "biotoolsID": "hi-cgan", "biotoolsCURIE": "biotools:hi-cgan", "version": [], "otherID": [], "relation": [], "function": [], "toolType": [], "topic": [], "operatingSystem": [], "language": [], "license": null, "collectionID": [], "maturity": null, "cost": null, "accessibility": null, "elixirPlatform": [], "elixirNode": [], "elixirCommunity": [], "link": [], "download": [], "documentation": [], "publication": [], "credit": [], "owner": "joachimwolff", "additionDate": "2025-04-09T09:58:29.019039Z", "lastUpdate": "2025-04-09T09:59:16.835262Z", "editPermission": { "type": "private", "authors": [] }, "validated": 0, "homepage_status": 0, "elixir_badge": 0, "confidence_flag": null } ] }